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protein expression

An Epigenetic GPI Anchor Defect Impairs TLR4 Signaling in the B Cell Transdifferentiation Model for Primary Human Monocytes BLaER1

[Scientific Reports] The authors identified an important caveat when investigating TLR4-driven signaling in BLaER1 cells. They showed that this model contained glycosylphosphatidylinositol anchor-deficient cells, which lacked CD14 surface expression when differentiated to monocytes, resulting in diminished LPS/TLR4 but not TLR7/TLR8 responsiveness.

Analysis of Extracellular Vesicles as a Potential Index for Monitoring Differentiation of Neural Lineage Cells from Induced Pluripotent Stem Cells

[Journal of Bioscience and Bioengineering] Researchers evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson's disease.

Norcantharidin Combined with Paclitaxel Induces Endoplasmic Reticulum Stress Mediated Apoptotic Effect in Prostate Cancer Cells by Targeting SIRT7 Expression

[Environmental Toxicology] Scientists showed that cell viability and proliferative PC3 and DU145 rates were effectively inhibited after norcantharidin-paclitaxel combination.

Inhibition of Stearoyl-CoA Desaturase by Sterculic Oil Reduces Proliferation and Induces Apoptosis in Prostate Cancer Cell Lines

[Nutrition and Cancer] The authors evaluated the effects of sterculic oil from Sterculia apetala seeds on proliferation, cell cycle and apoptosis in prostate cancer cells.

Curcumin Attenuates Adriamycin-Resistance of Acute Myeloid Leukemia by Inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 Axis

[Laboratory Investigation] Scientists investigated the mechanism by which curcumin affected the resistance of acute myeloid leukemia to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.

Placental Response to Maternal SARS-CoV-2 Infection

[Scientific Reports] Using a cohort of 66 COVID-19-positive women in late pregnancy, we correlated clinical parameters with disease severity, placental histopathology, and the expression of viral entry and Interferon-induced transmembrane antiviral transcripts.

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