Consequences of CRISPR-Cas9-Mediated CFTR Knockout in Human Macrophages

Researchers created a stable cystic fibrosis transmembrane conductance regulator (CFTR) knockout in human macrophages in order to study how CFTR regulates macrophage function.
[Frontiers in Immunology]
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DAXX-Inducing Phytoestrogens Inhibit ER+ Tumor Initiating Cells and Delay Tumor Development

Investigators aimed to identify a death-associated factor 6 (DAXX)-inducing agent to inhibit tumor initiating cells and prevent proliferation of the tumor.
[npj Breast Cancer]
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Design and Validation of Liposomal ApoE2 Gene Delivery System to Evade Blood-Brain Barrier for Effective Treatment of Alzheimer’s Disease

Researchers demonstrated efficient brain-targeted delivery of apolipoprotein E 2 (ApoE2) encoding plasmid DNA using glucose transporter-1 targeted liposomes.
[Molecular Pharmaceutics]
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Sequence-Based Prediction of SARS-CoV-2 Vaccine Targets Using a Mass Spectrometry-Based Bioinformatics Predictor Identifies Immunogenic T Cell Epitopes

The authors leveraged bioinformatics binding prediction tools for human leukocyte antigen (HLA)-I and HLA-II alleles that were developed using mass spectrometry-based profiling of individual HLA-I and HLA-II alleles to predict peptide binding to diverse allele sets.
[Genome Medicine]
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Yap is Crucial for CAR‐Driven Hepatocyte Proliferation, but not for Induction of Drug Metabolism Genes in Mice

Scientists investigated a direct role of Yap in constitutive androstane receptor (CAR)‐driven hepatomegaly and hepatocyte proliferation using hepatocyte‐specific Yap‐KO mice. AAV8‐TBG‐CRE vector was injected to Yap‐floxed mice for achieving hepatocyte‐specific Yap deletion followed by TCPOBOP‐treatment.
[Hepatology]
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Broccoli Extract Increases Drug-Mediated Cytotoxicity towards Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma

Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
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Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System

The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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Long Non-Coding RNA MIR503HG Inhibits the Proliferation, Migration and Invasion of Colon Cancer Cells via MiR-107/Par4 Axis

MIR503HG negatively regulated its target miR-107. MiR-107 overexpression reversed the anti-tumor effects of MIR503HG overexpression on colon cancer cells. Par4 was a target of miR-107, which was positively regulated by MIR503HG. The promoting effects of MIR503HG silencing on colon cancer cells were eliminated by Par4 overexpression.
[Experimental Cell Research]
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
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SARS-CoV-2 Can Infect the Placenta and Is Not Associated with Specific Placental Histopathology: A Series of 19 Placentas from COVID-19-Positive Mothers

Researchers examined 19 COVID-19 exposed placentas for histopathologic findings, and for expression of ACE2, and TMPRSS2 by immunohistochemistry.
[Modern Pathology]
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Cytoprotective Autophagy Induction by Withaferin A in Prostate Cancer Cells Involves GABARAPL1

Researchers confirmed autophagy induction by withaferin A (WA) treatment by transmission electron microscopy using three prostate cancer cell lines. Fourteen common genes altered by 8‐ and 16‐hour exposure to WA were identified from human autophagy PCR array and these results were consistent with the RNA‐seq data.
[Molecular Carcinogenesis]
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