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pulmonary cells

Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

[American Journal of Physiology-Cell Physiology] Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.

ERRFI1 Induces Apoptosis of Hepatocellular Carcinoma Cells in Response to Tryptophan Deficiency

[Cell Death Discovery] The authors showed that ERRFI1 was upregulated in sensitive hepatocellular carcinoma (HCC) cells, but not in resistant HCC cells, in response to tryptophan deficiency, and ERRFI1 expression level positively correlated with HCC patient overall survival.

Cancer Cells with Defective RB and CDKN2A Are Resistant to the Apoptotic Effects of Rapamycin

[Cancer Letters] Scientists observed that DU145 prostate and NCI–H2228 lung cancer cells were resistant to the cytotoxic effect of rapamycin.

Autophagic Secretion of HMGB1 from Cancer-Associated Fibroblasts Promotes Metastatic Potential of Non-Small Cell Lung Cancer Cells via NFκB Signaling

[Cell Death & Disease] Researchers reported that autophagy was upregulated in lung cancer-associated cancer-associated fibroblasts (CAFs) compared to normal fibroblasts, and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer cell migration and invasion.

MRTF-a-NF-κB/p65 Axis-Mediated PDL1 Transcription and Expression Contributes to Immune Evasion of Non-Small-Cell Lung Cancer via TGF-β

[Experimental and Molecular Medicine] Researchers defined a new signaling pathway that regulated the transcription and expression of PD-L1 upon TGF-β treatment, which might have a significant impact on research into the application of immunotherapy in treating lung cancer.

Inhaled Sphingosine Has No Adverse Side Effects in Isolated Ventilated and Perfused Pig Lungs

[Scientific Reports] Scientists tested whether sphingosine has any adverse effects in the respiratory tract when applied into isolated ventilated and perfused lungs. A four hour ex vivo lung perfusion run using minipig lungs was performed.

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