regulatory T cells

[Cell Research] The authors identified K2P18.1 as a central translator of the T cell receptor signal into the thymus-derived Treg (tTreg) selection process.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Blood] The authors performed whole-genome sequencing of 150 adult T cell leukemia/lymphoma (ATL) cases and revealed the overarching landscape of genetic alterations in ATL.

[Molecular Therapy-Nucleic Acids] A type of smart exosomes was developed, in which the exosome surface was functionally engineered with CD62L and OX40L by forced expression of the genes in the donor cells.

[Molecular Medicine] CircRNA microarray was used to observe the expression of candidate circRNAs in CD4+ T cells collected from different groups. Real-time PCR and Western blot were conducted to observe the changes in the expression of different miRNAs, mRNAs and proteins.

[Brazilian Journal of Medical and Biological Research] Lower Foxp3 and higher Bcl-6, ICOS, and PD-1 mRNA expression levels were found in patients with dilated cardiomyopathy (DCM). Plasma interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-21 levels were significantly increased in DCM cases.