The Fellowship of Regulatory and Tissue-Resident Memory Cells

T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies.
[Mucosal Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

PI3Kγδ Inhibitor plus Radiation Enhances the Antitumor Immune Effect of PD-1 Blockade in Syngenic Murine Breast Cancer and Humanized Patient-Derived Xenograft Model

Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.
[European Journal of Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

BTN2A2 Protein Negatively Regulates T Cells to Ameliorate Collagen-Induced Arthritis in Mice

Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment.
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Site-Specific PEGylation of Interleukin-2 Enhances Immunosuppression via the Sustained Activation of Regulatory T Cells

The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.
[Nature Biomedical Engineering]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Gut Epithelial IL-27 Confers Intestinal Immunity through the Induction of Intraepithelial Lymphocytes

Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.
[Journal of Experimental Medicine]
[zotpress userid=” items=’SZPSEPQ8′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

TGF-β-Induced CD4+ FoxP3+ Regulatory T Cell-Derived Extracellular Vesicles Modulate Notch1 Signaling through miR-449a and Prevent Collagen-Induced Arthritis in a Murine Model

Considering that the stability and plasticity of nTregs remain major challenges in vivo, scientists established extracellular vesicles derived from in vitro TGF-β-induced Treg cells and assessed their functions in a murine model of autoimmune arthritis.
[Cellular & Molecular Immunology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Single-Cell Profiling Defines the Prognostic Benefit of CD39high Tissue Resident Memory CD8+ T Cells in Luminal-Like Breast Cancer

By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.
[Communications Biology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Characterization of Peri-Implantation Endometrial Treg and Identification of an Altered Phenotype in Recurrent Pregnancy Loss

Researchers identified an endometrial Treg transcriptomic signature and validated an enhanced regulatory phenotype compared to peripheral blood Treg.
[Mucosal Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Delayed Administration of Ixazomib Modifies the Immune Response and Prevents Chronic Graft-versus-Host Disease

Investigators aimed to modify the immune response in the long term after allogeneic bone marrow transplantation by using the proteasome inhibitor ixazomib at the late stages of the post-transplant period.
[Bone Marrow Transplantation]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
[Stem Cell Research & Therapy]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.
[Frontiers in Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share