regulatory T cells

[Scientific Reports] Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment.

[Nature Biomedical Engineering] The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.

[Journal of Experimental Medicine] Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.

[Bone Marrow Transplantation] Investigators aimed to modify the immune response in the long term after allogeneic bone marrow transplantation by using the proteasome inhibitor ixazomib at the late stages of the post-transplant period.

[Communications Biology] By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.

[Mucosal Immunology] Researchers identified an endometrial Treg transcriptomic signature and validated an enhanced regulatory phenotype compared to peripheral blood Treg.