regulatory T cells

[Mucosal Immunology] β7 deficiency and MAdCAM-1 blockade specifically depleted antibody secreting cells from the colonic LP, leading to a fecal pan-immunoglobulin deficit, severe colitis, and alterations of microbiota composition.

[Blood] Scientists analyzed the effect of decitabine on T-cell subpopulations in immune thrombocytopenia in vitro and in vivo. They found that low-dose decitabine promoted the generation and differentiation of regulatory T cells and augmented their immunosuppressive function.

[Nature Immunology] Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor sequencing to map mouse adipose Treg cells, scientists identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns.

[Scientific Reports] The authors reported a phenotypic screening of a human secretome library in human Treg cells utilising a high throughput flow cytometry technology.

[Cancer Cell] Researchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.

[Nature Immunology] By reinstating Foxp3 protein expression and suppressor function in cells expressing a reversible Foxp3 null allele in severely diseased mice, researchers found that the resulting single pool of rescued Treg cells normalized immune activation, quelled severe tissue inflammation, reversed fatal autoimmune disease and provided long-term protection against them.