CD70 Expression Determines the Therapeutic Efficacy of Expanded Human Regulatory T Cells

Scientists showed that after prolonged in vitro stimulation, a significant proportion of human regulatory T cells gained stable CD70 expression while losing CD27.
[Communications Biology]
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Pulmonary Paracoccidioidomycosis in AhR Deficient Hosts Is Severe and Associated with Defective Treg and Th22 Responses

The lungs of AhR−/− mice showed increased presence Th17 cells concomitant with reduced numbers of Th1, Th22 and Foxp3+ Treg cells.
[Scientific Reports]
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Impaired Estrogen Signaling Underlies Regulatory T Cell Loss-of-Function in the Chronically Inflamed Intestine

Using a strain of congenic SAMP mice engineered to lack global expression of ERβ, investigators observed dramatic, female-specific exacerbation of intestinal inflammation accompanied by significant reductions in intestinal regulatory T cell frequency and function.
[Proceedings of the National Academy of Sciences of the United States of America]
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Tumor Invasion in Draining Lymph Nodes Is Associated with Treg Accumulation in Breast Cancer Patients

Researchers studied regulatory T cells from matched tumor-invaded and non-invaded tumor-draining lymph node, and breast tumors.
[Nature Communications]
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Discovery of CD80 and CD86 as Recent Activation Markers on Regulatory T Cells by Protein-RNA Single-Cell Analysis

The authors quantified the single-cell expression of 397 genes at the mRNA level and up to 68 proteins using oligo-conjugated antibodies in 43,656 primary CD4+ T cells isolated from the blood and 31,907 CD45+ cells isolated from the blood and matched duodenal biopsies.
[Genome Medicine]
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