High-Salt Diet Mediates Interplay between NK Cells and Gut Microbiota to Induce Potent Tumor Immunity

The authors reported that high-salt diet induces natural killer cell–mediated tumor immunity by inhibiting PD-1 expression while enhancing IFNγ and serum hippurate.
[Science Advances]
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scRNA-Seq of Human Vitiligo Reveals Complex Networks of Subclinical Immune Activation and a Role for CCR5 in Treg Function

Scientists performed single-cell RNA sequencing on affected and unaffected skin from patients with vitiligo, as well as healthy controls, to define the role of each cell type in coordinating autoimmunity during disease progression.
[Science Translational Medicine]
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PPM1D Is a Potential Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma

Protein phosphatase magnesium-dependent 1 delta (PPM1D) mRNA expression was significantly higher in several human cancers, including hepatocellular carcinoma (HCC), than in the corresponding normal human tissues. The PPM1D mRNA high expression in HCC was significantly correlated with poor prognosis.
[Aging]
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Low-Dose Decitabine Modulates T-Cell Homeostasis and Restores Immune Tolerance in Immune Thrombocytopenia

Scientists analyzed the effect of decitabine on T-cell subpopulations in immune thrombocytopenia in vitro and in vivo. They found that low-dose decitabine promoted the generation and differentiation of regulatory T cells and augmented their immunosuppressive function.
[Blood]
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Antibody Secreting Cells Are Critically Dependent on Integrin α4β7/MAdCAM-1 for Intestinal Recruitment and Control of the Microbiota during Chronic Colitis

β7 deficiency and MAdCAM-1 blockade specifically depleted antibody secreting cells from the colonic LP, leading to a fecal pan-immunoglobulin deficit, severe colitis, and alterations of microbiota composition.
[Mucosal Immunology]
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Secretome Screening Reveals Immunomodulating Functions of IFNα-7, PAP and GDF-7 on Regulatory T-cells

The authors reported a phenotypic screening of a human secretome library in human Treg cells utilising a high throughput flow cytometry technology.
[Scientific Reports]
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Insulin Signaling Establishes a Developmental Trajectory of Adipose Regulatory T Cells

Using single-cell ATAC-sequencing and paired single-cell RNA and T cell receptor sequencing to map mouse adipose Treg cells, scientists identified CD73hiST2lo and CD73loST2hi subsets with distinct clonal expansion patterns.
[Nature Immunology]
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Anti-PD-1/L1 Lead-In before MAPK Inhibitor Combination Maximizes Antitumor Immunity and Efficacy

Researchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.
[Cancer Cell]
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Regulatory T Cells Function in Established Systemic Inflammation and Reverse Fatal Autoimmunity

By reinstating Foxp3 protein expression and suppressor function in cells expressing a reversible Foxp3 null allele in severely diseased mice, researchers found that the resulting single pool of rescued Treg cells normalized immune activation, quelled severe tissue inflammation, reversed fatal autoimmune disease and provided long-term protection against them.
[Nature Immunology]
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Lymph Node Stromal Cell–Intrinsic MHC Class II Expression Promotes MHC Class I–Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells

Scientists examined the cellular and molecular elements that promote CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice.
[Journal of Immunology]
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A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

Researchers identified gut bacteria that synthesized isoalloLCA from 3-oxolithocholic acid and uncovered a gene cluster responsible for the conversion in members of the abundant human gut bacterial phylum Bacteroidetes.
[Cell Host & Microbe]
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