regulatory T cells

[Journal of Investigative Dermatology] Researchers found IL-33 upregulation in human skin fibrosis. Mice with germline deletion of IL-33 receptor showed markedly exacerbated skin fibrosis in association with significantly increased T helper 2 cell to regulatory T cell ratio in the skin.

[Sangamo Therapeutics, Inc.] Sangamo Therapeutics, Inc. announced dosing of the first patient in the Phase I/II STEADFAST clinical study evaluating TX200, a wholly-owned autologous CAR-Treg cell therapy product candidate for the prevention of immune-mediated rejection in HLA-A2 mismatched kidney transplantation from a living donor.

[EMBO Journal] miPEP31 was highly expressed in Foxp3+ Tregs and significantly promoted the differentiation of Tregs without affecting their inhibitory ability.

[Science Immunology] Investigators reported that caspase-8 was a central regulator of regulatory T cell homeostasis in a context-specific manner that was decisive during immune responses.

[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.

[Science Immunology] Investigators review transforming growth factor–β1 (TGF-β1) signaling in T regulatory cell (Treg) development and function and discuss knowledge gaps, future research, and the TGF-β1/Treg axis in the context of cancer immunotherapy and fibrosis.