Tag results:
regulatory T cells
Human Immunology News
Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma
[Clinical Cancer Research] Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.
Immune Regulation News
RORγt Phosphorylation Protects against T Cell-Mediated Inflammation
[Cell Reports] Investigators reported that serine 182 phosphorylation was a major post-translational modification was not involved in thymic T cell development and effector T cell differentiation.
Immune Regulation News
Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1 Resistant Melanoma
[Cancer Immunology Research] Using an aggressive melanoma tumor model, the authors targeted PSGL-1 in tumor-bearing mice and found increased effector CD4+ and CD8+ T cell responses and decreased regulatory T cells in tumors.
Immune Regulation News
BioMed X Institute and Merck KGaA, Darmstadt, Germany, Start Second Research Project in Immunology
[BioMedX] A German independent research institute, BioMed X, announced the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ in collaboration with Merck KGaA, Darmstadt, Germany.
Immunology of Infectious Disease News
Helios Expressing Regulatory T Cells Are Correlated with Decreased IL-2 Producing CD8 T Cells and Antibody Diversity in Mozambican Individuals Living Chronically with HIV-1
[BMC Immunology] Investigators analyzed the profile of regulatory T cells and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ, and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1.
Immune Regulation News
Immune Phenotype of the CD4+ T Cells in the Aged Lymphoid Organs and Lacrimal Glands
[GeroScience] Effector T helper 1 genes were highly upregulated on aged Tregs, including the master regulator Tbx21.