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regulatory T cells

Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma

[Clinical Cancer Research] Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.

RORγt Phosphorylation Protects against T Cell-Mediated Inflammation

[Cell Reports] Investigators reported that serine 182 phosphorylation was a major post-translational modification was not involved in thymic T cell development and effector T cell differentiation.

Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1 Resistant Melanoma

[Cancer Immunology Research] Using an aggressive melanoma tumor model, the authors targeted PSGL-1 in tumor-bearing mice and found increased effector CD4+ and CD8+ T cell responses and decreased regulatory T cells in tumors.

BioMed X Institute and Merck KGaA, Darmstadt, Germany, Start Second Research Project in Immunology

[BioMedX] A German independent research institute, BioMed X, announced the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ in collaboration with Merck KGaA, Darmstadt, Germany.

Helios Expressing Regulatory T Cells Are Correlated with Decreased IL-2 Producing CD8 T Cells and Antibody Diversity in Mozambican Individuals Living Chronically with HIV-1

[BMC Immunology] Investigators analyzed the profile of regulatory T cells and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ, and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1.

Immune Phenotype of the CD4+ T Cells in the Aged Lymphoid Organs and Lacrimal Glands

[GeroScience] Effector T helper 1 genes were highly upregulated on aged Tregs, including the master regulator Tbx21.

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