regulatory T cells

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that acute Listeria monocytogenes infection produced a phenotypically and functionally complex Treg response comprising two separate suppressor cell subpopulations, with an early Treg peak occurring at 24 hour post-infection and a later peak arising by day seven.

[Cell Reports] Scientists investigated the impact of mammary tumorigenesis on regulatory T cells in distant organs and how this affected multi-organ metastatic disease.

[Molecular Therapy] Investigators treated three children suffering from severe, therapy-refractory GvHD with polyclonally expanded regulatory T cells generated from the original stem cell donor.

[International Journal of Biological Macromolecules] The authors discuss the role of TGF-β signaling in proliferation, metastasis and therapy response of prostate cancer cells and in order to improve knowledge towards its regulation, upstream mediators of TGF-β such as non-coding RNAs are described.

[Nature Reviews Immunology] A pivotal event in the history of IL-2 research was solving the crystal structure of IL-2 bound to its tripartite receptor, which spurred the development of cell type-selective engineered IL-2 products.

[Molecular & Cellular Proteomics] Co-culturing primary CD8+ T cells with Tregs only modestly affected the CD8+ surfaceome but did partially reverse activation-induced surfaceomic changes.