renal inflammation

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

[Circulation Research] In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.

[Human Cell] Scientists investigated whether icrovesicles derived from human Wharton’s Jelly mesenchymal stromal cells regulated macrophage polarization and ameliorated renal fibrosis following ischemia-PN via transferring hepatocyte growth factor.

[Cells] Five groups of pigs were studied after 16 weeks of renovascular disease (RVD), RVD treated four weeks earlier with either percutaneous transluminal renal angioplasty or MSC-derived extracellular vesicles, and normal controls.