Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension

In human endothelial cells, a striking correlation was observed between the degree of endothelial cell activation as reflected by intracellular adhesion molecule 1, isoLG-adduct accumulation and intracellular GAS6 levels.
[Circulation Research]
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Microvesicles Derived from Human Umbilical Cord Mesenchyme Promote M2 Macrophage Polarization and Ameliorate Renal Fibrosis Following Partial Nephrectomy via Hepatocyte Growth Factor

Scientists investigated whether icrovesicles derived from human Wharton’s Jelly mesenchymal stromal cells regulated macrophage polarization and ameliorated renal fibrosis following ischemia-PN via transferring hepatocyte growth factor.
[Human Cell]
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Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease

Five groups of pigs were studied after 16 weeks of renovascular disease (RVD), RVD treated four weeks earlier with either percutaneous transluminal renal angioplasty or MSC-derived extracellular vesicles, and normal controls.
[Cells]
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