reporter assay

[Cell & Bioscience] Scientists explored the function and characterize the underlying mechanism of long noncoding RNA RNF144A-AS1 in gastric cancer metastasis and outgrowth.

[Hepatology] Hepatocyte-specific inactivation of ZBTB20 in mice led to a remarkable increase in lipoprotein lipase (LPL) expression at the mRNA and protein levels in adult liver, in which LPL protein was mainly localized onto sinusoidal epithelial cells and Kupffer cells.

[Journal of Gastroenterology and Hepatology] The authors aimed to evaluate the role of O-GlcNAc transferase (OGT) in hepatic stellate cells (HSCs) and its consequent role in liver fibrosis. RNA-seq showed that OGT knockdown in HSCs modulated key signaling pathways involved in HSC activation.

[British Journal of Cancer] Researchers reported that MCOLN2 expression is significantly elevated in prostate cancer tissues, and associated with poor prognosis. Overexpression of MCOLN2 promoted prostate cancer cells proliferation, migration and invasion.

[Oncology Reports] Researchers evaluated the role of the lncRNA TINCR ubiquitin domain containing TINCR in cutaneous malignant melanoma in vitro and in vivo.

[Thoracic Cancer] Researchers identified the precise role of circular RNA circ_0058357 in the functional properties of DDP-resistant non-small cell lung cancer cells.