Latent Factor Modeling of scRNA-Seq Data Uncovers Dysregulated Pathways in Autoimmune Disease Patients

The authors compared four state-of-the-art methods and propose an approach to assign derived latent factors to pathway activities and specific cell subsets.
[iScience]
Palla, G., & Ferrero, E. (2020). Latent factor modelling of scRNA-seq data uncovers dysregulated pathways in autoimmune disease patients. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101451 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

The authors identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
Full Article

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Comparative Study between Human Mesenchymal Stem Cells and Etanercept as Immunomodulatory Agents in Rat Model of Rheumatoid Arthritis

Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
[Immunologic Research]
El-Gendy, H., Hawass, S. E.-D., Awad, M., Mohsen, M. A., Amin, M., Abdalla, H. A., Fouad, S., & Lotfy, A. (2020). Comparative study between human mesenchymal stem cells and etanercept as immunomodulatory agents in rat model of rheumatoid arthritis. Immunologic Research. https://doi.org/10.1007/s12026-020-09132-w Cite
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Hydroxychloroquine in Rheumatic Autoimmune Disorders and Beyond

By influencing several cellular pathways through different mechanisms, chloroquine and hydroxychloroquine inhibited multiple endolysosomal functions, including autophagy, as well as endosomal Toll‐like receptor activation and calcium signaling.
[EMBO Molecular Medicine]
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Distinct Synovial Tissue Macrophage Subsets Regulate Inflammation and Remission in Rheumatoid Arthritis

Investigators used single-cell transcriptomics to profile 32,000 synovial tissue macrophages and identified phenotypic changes in patients with early/active rheumatoid arthritis (RA), treatment-refractory/active RA and RA in sustained remission.
[Nature Medicine]
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., … Kurowska-Stolarska, M. (2020). Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-020-0939-8 Cite
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COVID-19 Revisiting Inflammatory Pathways of Arthritis

The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
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The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
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The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
Abstract

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Amplification of Transglutaminase 2 Enhances Tumor-Promoting Inflammation in Gastric Cancers

Scientists investigated a novel role for transglutaminase 2 (TGM2) in the development of tumor-promoting inflammation and recruitment of tumor-associated macrophages to gastric cancer (GC) tissues. When estimated by array comparative genomic hybridization and droplet digital PCR, the copy numbers of the TGM2 gene were amplified in 13.6% of GC patients and positively associated with TGM2 expression.
[Experimental and Molecular Medicine]
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