CreakyJoints Español Awarded $1Million Grant to Promote Health Equity and Improve Health Outcomes Among Hispanics Living with Rheumatoid Arthritis

CreakyJoints® Español announced that the Bristol Myers Squibb Foundation has funded the “RA Hispanic Outreach Program,” a $1 million, two-year grant to improve relationships between Hispanic people living with rheumatoid arthritis (RA) and rheumatologists.
[CreakyJoints® Español (BusinessWire, Inc.)]
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A Shedding Soluble Form of Interleukin-17 Receptor D Exacerbates Collagen-Induced Arthritis through Facilitating TNF-α-Dependent Receptor Clustering

Investigators showed that soluble glycosylated interleukin-17 receptor D, which was produced by proteolytic cleavage, enhanced TNF-α-induced rheumatoid arthritis.
[Cellular & Molecular Immunology]
Liu, S., Fu, Y., Mei, K., Jiang, Y., Sun, X., Wang, Y., Ren, F., Jiang, C., Meng, L., Lu, S., Qin, Z., Dong, C., Wang, X., Chang, Z., & Yang, S. (2020). A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering. Cellular & Molecular Immunology, 1–13. https://doi.org/10.1038/s41423-020-00548-w Cite
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Chitinase-3 Like-Protein-1 Function and Its Role in Diseases

Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) binds to chitin, heparin, and hyaluronic acid, and is regulated by ECM changes, cytokines, growth factors, drugs, and stress. This review summarizes the potential roles and mechanisms of CHI3L1 in oncogenesis and disease pathogenesis, then posits investigational strategies for targeted therapies.
[Signal Transduction and Targeted Therapy]
Zhao, T., Su, Z., Li, Y., Zhang, X., & You, Q. (2020). Chitinase-3 like-protein-1 function and its role in diseases. Signal Transduction and Targeted Therapy, 5(1), 1–20. https://doi.org/10.1038/s41392-020-00303-7 Cite
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Analysis of Chromatin Organization and Gene Expression in T Cells Identifies Functional Genes for Rheumatoid Arthritis

Scientists collected ATAC-seq, Hi-C, Capture Hi-C and nuclear RNA-seq data in stimulated CD4+ T cells over 24 hours, to identify functional enhancers regulating gene expression.
[Nature Communications]
Yang, J., McGovern, A., Martin, P., Duffus, K., Ge, X., Zarrineh, P., Morris, A. P., Adamson, A., Fraser, P., Rattray, M., & Eyre, S. (2020). Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis. Nature Communications, 11(1), 4402. https://doi.org/10.1038/s41467-020-18180-7 Cite
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Accumulation of Synovial Fluid CD19+CD24hiCD27+ B Cells Was Associated with Bone Destruction in Rheumatoid Arthritis

Researchers investigated whether rheumatoid arthritis synovial fluid CD19+CD24hiCD27+ B cells were increased and associated with bone destruction.
[Scientific Reports]
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Calcium-Sensing Receptor-Mediated NLRP3 Inflammasome Response to Calciprotein Particles Drives Inflammation in Rheumatoid Arthritis

Scientists showed that monocytes engulfed colloidal calciprotein particles via macropinocytosis, and this process was strictly dependent on calcium-sensing receptor signaling triggered by increases in [Ca2+]ex.
[Nature Communications]
Jäger, E., Murthy, S., Schmidt, C., Hahn, M., Strobel, S., Peters, A., Stäubert, C., Sungur, P., Venus, T., Geisler, M., Radusheva, V., Raps, S., Rothe, K., Scholz, R., Jung, S., Wagner, S., Pierer, M., Seifert, O., Chang, W., … Wagner, U. (2020). Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nature Communications, 11(1), 4243. https://doi.org/10.1038/s41467-020-17749-6 Cite
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Acidosis Induces Synovial Fibroblasts to Release Vascular Endothelial Growth Factor via Acid-Sensitive Ion Channel 1a

Scientists investigated the role of tissue acidification in microvascular formation of arthritic synovial tissue and the effect of acid-sensitive ion channel 1 on vascular endothelial growth factor release from arthritic synovial tissue.
[Laboratory Investigation]
Qian, X., Zhang, Y., Tao, J., Niu, R., Song, S., Wang, C., Peng, X., & Chen, F. (2020). Acidosis induces synovial fibroblasts to release vascular endothelial growth factor via acid-sensitive ion channel 1a. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-0423-6 Cite
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Latent Factor Modeling of scRNA-Seq Data Uncovers Dysregulated Pathways in Autoimmune Disease Patients

The authors compared four state-of-the-art methods and propose an approach to assign derived latent factors to pathway activities and specific cell subsets.
[iScience]
Palla, G., & Ferrero, E. (2020). Latent factor modelling of scRNA-seq data uncovers dysregulated pathways in autoimmune disease patients. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101451 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

The authors identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
Yang, L., Wang, H., Yang, X., Wu, Q., An, P., Jin, X., Liu, W., Huang, X., Li, Y., Yan, S., Shen, S., Liang, T., Min, J., & Wang, F. (2020). Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-00253-0 Cite
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Auranofin Mitigates Systemic Iron Overload and Induces Ferroptosis via Distinct Mechanisms

Scientists identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells.
[Signal Transduction and Targeted Therapy]
Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms | Signal Transduction and Targeted Therapy. (n.d.). Retrieved July 31, 2020, from https://www.nature.com/articles/s41392-020-00253-0 Cite
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Comparative Study between Human Mesenchymal Stem Cells and Etanercept as Immunomodulatory Agents in Rat Model of Rheumatoid Arthritis

Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
[Immunologic Research]
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