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rheumatoid arthritis

Syndecan-2 Regulates PAD2 to Exert Antifibrotic Effects on RA-ILD Fibroblasts

[Scientific Reports] Scientists demonstrated that the expression of peptidylarginine deiminase 2 (PAD2), an enzyme that catalyzes protein citrullination, was increased in lung homogenates from subjects with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and their lung fibroblasts.

Surface Ig Variable Domain Glycosylation Affects Autoantigen Binding and Acts as Threshold for Human Autoreactive B Cell Activation

[Science Advances] Combining crystallography, glycobiology, and functional B cell assays allowed researchers to dissect key characteristics of variable domain glycans on human B cell biology.

Revolo Biotherapeutics Receives MHRA Approval for Two Phase II Clinical Trials of ‘1805 in Autoimmune Diseases in the United Kingdom

[Revolo Biotherapeutics] Revolo Biotherapeutics announced that it has received approval from the Medicines and Healthcare products Regulatory Agency to commence two Phase II clinical trials to evaluate its immune-resetting drug candidate, ‘1805, in patients with autoimmune diseases, one in people with moderate to severe active Rheumatoid Arthritis.

TNF Antagonist Sensitizes Synovial Fibroblasts to Ferroptotic Cell Death in Collagen-Induced Arthritis Mouse Models

[Nature Communications] Scientists showed, using a collagen-induced arthritis mouse model, that imidazole ketone erastin, a ferroptosis inducer, decreased fibroblast numbers in the synovium.

Immunomodulatory Matrix-Bound Nanovesicles Mitigate Acute and Chronic Pristane-Induced Rheumatoid Arthritis

[NPJ Regenerative Medicine] Isolated matrix-bound nanovesicles (MBV) were delivered via intravenous or peri-articular injection to rats with pristane-induced arthritis. The results of MBV administration were compared to intraperitoneal administration of methotrexate, the clinical standard of care.

Regulation of Activated T Cell Survival in Rheumatic Autoimmune Diseases

[Nature Reviews Rheumatology] Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.

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