NKX6-1 Mediates Cancer Stem-Like Properties and Regulates Sonic Hedgehog Signaling in Leiomyosarcoma

NKX6-1 enhanced in vitro tumor cell aggressiveness via upregulation of cell proliferation and anchorage-independent growth and promoted in vivo tumor growth.
[Journal of Biomedical Science]
Su, P.-H., Huang, R.-L., Lai, H.-C., Chen, L.-Y., Weng, Y.-C., Wang, C.-C., & Wu, C.-C. (2021). NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. Journal of Biomedical Science, 28(1), 32. https://doi.org/10.1186/s12929-021-00726-6 Cite
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PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
[Oncogenesis]
Yoon, C., Lu, J., Yi, B. C., Chang, K. K., Simon, M. C., Ryeom, S., & Yoon, S. S. (2021). PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas. Oncogenesis, 10(1), 1–14. https://doi.org/10.1038/s41389-020-00300-z Cite
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Lithocholic Bile Acid Induces Apoptosis in Human Nephroblastoma Cells: A Non-Selective Treatment Option

Scientists evaluated the effects of Lithocholic bile acid (LCA) on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used.
[Scientific Reports]
Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option | Scientific Reports. (n.d.). Retrieved November 23, 2020, from https://www.nature.com/articles/s41598-020-77436-w Cite
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GARP Promotes the Proliferation and Therapeutic Resistance of Bone Sarcoma Cancer Cells through the Activation of TGF-β

Silencing of GARP in bone sarcoma cell lines blocked their proliferation and induced apoptosis. In contrast, overexpression of GARP promoted their growth in vitro and in vivo and increased their resistance to DNA damage and cell death induced by etoposide, doxorubicin, and irradiation.
[Cell Death & Disease]

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The Translational Repressor 4E-BP1 Regulates RRM2 Levels and Functions as a Tumor Suppressor in Ewing Sarcoma Tumors

Investigators showed that the expression of the RRM2 protein is dependent on active protein synthesis and that 4E-BP1, a repressor of cap-dependent protein translation, specifically regulates the level of the ribonucleotide reductase (RRM2) protein.
[Oncogene]

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