sarcoma

[Oncogene] Researchers evaluated the effects of a selective G9a histone methyltransferase inhibitor on Ewing sarcoma metastatic process.

[Acta Pharmacologica Sinica] Two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.

[Lancet Oncology] Investigators evaluated the activity of pembrolizumab in classic and endemic Kaposi sarcoma with cutaneous extension requiring systemic treatment.

[Cancer Research] The authors focus on the role of leucine-rich repeat-containing protein (LRRC15) in cancer, including clinical trials involving LRRC15-targeted therapies, such as the ABBV-085 ADC for patients with LRRC15-positive tumors.

[Scientific Reports] Using immunohistochemistry, scientists investigated nectin cell adhesion molecule 4 (NECTIN4) expression in 74 tissue samples from angiosarcoma patients, finding variable NECTIN4 expression.

[Laboratory Investigation] Understanding the urgent need for improved treatments for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor and the limited cellular models available, the authors generated additional cell lines to study these rare cancers.