Aadi Bioscience Announces FDA Approval of Its First Product FYARRO for Patients with Locally Advanced Unresectable or Metastatic Malignant Perivascular Epithelioid Cell Tumor (PEComa)

Aadi Bioscience, Inc. announced that the US FDA has approved FYARRO for intravenous use for the treatment of adult patients with locally advanced unresectable or metastatic malignant PEComa.
[Aadi Bioscience, Inc.]
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Castleman Disease

VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.
[Nature Reviews Disease Primers]
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Loss of Mutual Protection between Human Osteoclasts and Chondrocytes in Damaged Joints Initiates Osteoclast-Mediated Cartilage Degradation by MMPs

Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).
[Scientific Reports]
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Rakovina Therapeutics Partners with St. Baldrick’s Foundation to Research and Develop New Treatments for Childhood Bone Cancer

Rakovina Therapeutics, Inc. announced that the company has been selected to join a three year US $975,000 research program funded by the St. Baldrick’s Foundation Martha’s BEST Grant for All, which is aimed at developing new treatments for Ewing sarcoma, an aggressive bone and soft tissue cancer in children and young adults.
[Rakovina Therapeutics, Inc.]
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Noncanonical Roles of p53 in Cancer Stemness and Their Implications in Sarcomas

The authors address the noncanonical roles of p53 and their implications in sarcoma initiation and progression.
[Cancer Letters]
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Sumitomo Dainippon Pharma Oncology Announces First Patient Dosed in Phase 1 Dose Expansion Study of TP-1287 in Patients with Sarcoma

Sumitomo Dainippon Pharma Oncology, Inc. announced that the first patient has been dosed in the Phase I dose expansion portion of the study evaluating the investigational agent TP-1287, an oral cyclin-dependent kinase 9 inhibitor, in patients with sarcoma.
[Sumitomo Dainippon Pharma Oncology, Inc.]
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GenFleet Announces First Patient Dosed in Phase Ib/II Trial of TGF-β R1 Inhibitor in Combination with PD-1 Inhibitor in Global Multi-Center Research

GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.
[GenFleet Therapeutics]
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Low-Grade Endometrial Stromal Sarcoma-Like Tumors in Male with JAZF1 Gene Fusions

Researchers reported two new cases of low-grade endometrial stromal sarcoma-like sarcoma in male patients, one presenting as a periprostatic/peri-rectal mass with a JAZF1-GLI3 fusion, while the other as a paratesticular mass with a JAZF1-PHF1 fusion.
[Genes Chromosomes & Cancer]
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Insertional Activation of STAT3 and LCK by HIV-1 Proviruses in T Cell Lymphomas

Scientists showed that HIV-1 proviruses integrated in the first introns of signal transducer and activator of transcription 3 and lymphocyte-specific protein tyrosine kinase could play an important role in the development of T cell lymphomas.
[Science Advances]
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Overview of Malignant Soft-Tissue Sarcomas of the Limbs

Following a review of over 4,000 adult patients with limb sarcoma from our specialist soft-tissue tumour database, scientists summarize the literature and their imaging findings, with emphasis on radiological hallmarks that can aide in diagnosis and management.
[Clinical Radiology]
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Novel TCR-like CAR-T Cells to Target an HLA*0201 Restricted Epitope from the Cancer-Testis Antigen SSX2 Display Strong Activity against Acute Myeloid Leukemia

Researchers developed a T cell receptor-like antibody that binds Synovial Sarcoma X breakpoint 2 (SSX2) peptide 41-49 in the context of HLA-A*-0201.
[Molecular Therapy-Methods & Clinical Development]
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