PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
[Oncogenesis]
Yoon, C., Lu, J., Yi, B. C., Chang, K. K., Simon, M. C., Ryeom, S., & Yoon, S. S. (2021). PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas. Oncogenesis, 10(1), 1–14. https://doi.org/10.1038/s41389-020-00300-z Cite
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Circulating Tumor DNA Is Detectable in Canine Histiocytic Sarcoma, Oral Malignant Melanoma, and Multicentric Lymphoma

Researchers used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the plasma of cancer-affected dogs. They detected circulating tumor DNA in 21/23 of histiocytic sarcoma, 2/8of oral melanoma, and 12/13 of lymphoma cases.
[Scientific Reports]
Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y Cite
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YAP/TAZ Inhibition Reduces Metastatic Potential of Ewing Sarcoma Cells

Investigators suggest that YAP/TAZ pathway inhibition may prevent Ewing sarcoma (EwS) cell dissemination and metastasis, justifying further preclinical development of YAP/TAZ inhibitors for EwS treatment.
[Oncogenesis]
Bierbaumer, L., Katschnig, A. M., Radic-Sarikas, B., Kauer, M. O., Petro, J. A., Högler, S., Gurnhofer, E., Pedot, G., Schäfer, B. W., Schwentner, R., Mühlbacher, K., Kromp, F., Aryee, D. N. T., Kenner, L., Uren, A., & Kovar, H. (2021). YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells. Oncogenesis, 10(1), 1–13. https://doi.org/10.1038/s41389-020-00294-8 Cite
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Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation

Researchers found that Lgr5, a receptor for Rspo and a potent mediator of Wnt/β-catenin signaling, marks a subset of activated satellite cells that contribute to muscle regeneration.
[Cell Reports]
Leung, C., Murad, K. B. A., Tan, A. L. T., Yada, S., Sagiraju, S., Bode, P. K., & Barker, N. (2020). Lgr5 Marks Adult Progenitor Cells Contributing to Skeletal Muscle Regeneration and Sarcoma Formation. Cell Reports, 33(12). https://doi.org/10.1016/j.celrep.2020.108535 Cite
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USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

The authors systematically inactivated deubiquitinating enzymes (DUBs) in mouse hematopoietic progenitors using in vivo small hairpin RNA (shRNA) screens. They found that multiple DUBs may be individually required for hematopoiesis and identify ubiquitin-specific protease 15 (USP15) as essential for hematopoietic stem cell maintenance in vitro and in transplantations and Usp15 knockout (KO) mice in vivo.
[Cell Reports]
USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells: Cell Reports. (n.d.). Retrieved January 4, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31522-9 Cite
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Single Cell Analysis Reveals Distinct Immune Landscapes in Transplant and Primary Sarcomas That Determine Response or Resistance to Immunotherapy

Scientists showed that transplant sarcomas are cured by PD-1 blockade and radiotherapy, but identical treatment failed in autochthonous sarcomas, which demonstrated immunoediting, decreased neoantigen expression, and tumor-specific immune tolerance.
[Nature Communications]
Wisdom, A. J., Mowery, Y. M., Hong, C. S., Himes, J. E., Nabet, B. Y., Qin, X., Zhang, D., Chen, L., Fradin, H., Patel, R., Bassil, A. M., Muise, E. S., King, D. A., Xu, E. S., Carpenter, D. J., Kent, C. L., Smythe, K. S., Williams, N. T., Luo, L., … Kirsch, D. G. (2020). Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. Nature Communications, 11(1), 6410. https://doi.org/10.1038/s41467-020-19917-0 Cite
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Recurrent FOS Rearrangement in Proliferative Fasciitis/Proliferative Myositis

c-FOS immunohistochemistry was negative in 45 cases of selected mesenchymal tumor types with epithelioid components that may histologically mimic PF/PM, including pleomorphic sarcoma with epithelioid features and epithelioid sarcoma.
[Modern Pathology]
Makise, N., Mori, T., Motoi, T., Shibahara, J., Ushiku, T., & Yoshida, A. (2020). Recurrent FOS rearrangement in proliferative fasciitis/proliferative myositis. Modern Pathology, 1–9. https://doi.org/10.1038/s41379-020-00725-2 Cite
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Aberrant Interaction of FUS with the U1 snRNA Provides a Molecular Mechanism of FUS Induced Amyotrophic Lateral Sclerosis

Investigators showed that ALS-associated Fused in Sarcoma (FUS) RNA-binding protein aberrantly contacts U1 snRNA at the Sm site with its zinc finger and traps snRNP biogenesis intermediates in human and murine motor neurons.
[Nature Communications]
Jutzi, D., Campagne, S., Schmidt, R., Reber, S., Mechtersheimer, J., Gypas, F., Schweingruber, C., Colombo, M., von Schroetter, C., Loughlin, F. E., Devoy, A., Hedlund, E., Zavolan, M., Allain, F. H.-T., & Ruepp, M.-D. (2020). Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis. Nature Communications, 11(1), 6341. https://doi.org/10.1038/s41467-020-20191-3 Cite
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Rafael Pharmaceuticals Partners with Sara’s Cure and SARC for the Launch of Phase 2 Clinical Trial for CPI-613® (devimistat) in Combination with Hydroxychloroquine for Patients with Clear Cell Sarcoma of Soft Tissue

Rafael Pharmaceuticals, Inc. announced it will initiate a Phase II clinical trial of CPI-613® in combination with hydroxychloroquine in patients with clear cell sarcoma of soft tissue. In partnership with Sara’s Cure and Sarcoma Alliance for Research through Collaboration (SARC), they will begin enrolling patients into the Simon two-stage design trial at sites across the US.
[Rafael Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]
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Eribulin as a First-Line Treatment for Soft Tissue Sarcoma Patients with Contraindications for Doxorubicin

Scientists retrospectively analyzed the efficacy and safety of first-line eribulin therapy for patients with advanced soft tissue sarcoma, unable to receive doxorubicin. Six of 28 patients who received eribulin as any line treatment received eribulin as a first-line treatment.
[Scientific Reports]
Tsuchihashi, K., Kusaba, H., Yoshihiro, T., Fujiwara, T., Setsu, N., Endo, M., Matsumoto, Y., Imajima, T., Shinohara, Y., Ito, M., Yamaga, S., Tanoue, K., Arimizu, K., Ohmura, H., Hanamura, F., Yamaguchi, K., Isobe, T., Ariyama, H., Nakashima, Y., … Baba, E. (2020). Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin. Scientific Reports, 10(1), 20896. https://doi.org/10.1038/s41598-020-77898-y Cite
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Lithocholic Bile Acid Induces Apoptosis in Human Nephroblastoma Cells: A Non-Selective Treatment Option

Scientists evaluated the effects of Lithocholic bile acid (LCA) on nephroblastoma. To test the effects of LCA, nephroblastoma cell line WT CLS1 was used.
[Scientific Reports]
Lithocholic bile acid induces apoptosis in human nephroblastoma cells: a non-selective treatment option | Scientific Reports. (n.d.). Retrieved November 23, 2020, from https://www.nature.com/articles/s41598-020-77436-w Cite
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