sarcoma

[Sumitomo Dainippon Pharma Oncology, Inc.] Sumitomo Dainippon Pharma Oncology, Inc. announced that the first patient has been dosed in the Phase I dose expansion portion of the study evaluating the investigational agent TP-1287, an oral cyclin-dependent kinase 9 inhibitor, in patients with sarcoma.

[GenFleet Therapeutics] GenFleet Therapeutics announced the first patient with metastatic sigmoid adenocarcinoma has been dosed in a Phase Ib/II trial of GFH018 in combination with toripalimab as part of global multi-center clinical research. There are broad indications for GFH018 in treating solid tumors with lower response rates to PD-1 inhibitors.

[Genes Chromosomes & Cancer] Researchers reported two new cases of low-grade endometrial stromal sarcoma-like sarcoma in male patients, one presenting as a periprostatic/peri-rectal mass with a JAZF1-GLI3 fusion, while the other as a paratesticular mass with a JAZF1-PHF1 fusion.

[Science Advances] Scientists showed that HIV-1 proviruses integrated in the first introns of signal transducer and activator of transcription 3 and lymphocyte-specific protein tyrosine kinase could play an important role in the development of T cell lymphomas.

[Clinical Radiology] Following a review of over 4,000 adult patients with limb sarcoma from our specialist soft-tissue tumour database, scientists summarize the literature and their imaging findings, with emphasis on radiological hallmarks that can aide in diagnosis and management.

[Molecular Therapy-Methods & Clinical Development] Researchers developed a T cell receptor-like antibody that binds Synovial Sarcoma X breakpoint 2 (SSX2) peptide 41-49 in the context of HLA-A*-0201.