Functional Convalescent Plasma Antibodies and Pre-Infusion Titers Shape the Early Severe COVID-19 Immune Response

Investigators performed deep profiling of SARS-CoV-2-specific antibody titer, Fc-receptor binding, and Fc-mediated functional assays in convalescent plasma (CP) units, as well as in plasma from hospitalized COVID-19 patients before and after CP administration.
[Nature Communications]
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Antibody Cocktail Effective against Variants of SARS-CoV-2

The authors analyzed the binding activity of six highly potent antibodies to the spike proteins of SARS-CoV-2 variants, assessed their neutralizing abilities with pseudovirus and authentic SARS-CoV-2 variants and evaluate efficacy of antibody cocktail in Delta SARS-CoV-2-infected hamster models as prophylactic and post-infection treatments.
[Journal of Biomedical Science]
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Modeling SARS-CoV-2 Propagation Using Rat Coronavirus-Associated Shedding and Transmission

Scientists used Sialodacryoadenitis Virus in rats to model the extent to which immune protection afforded by prior natural infection via high risk or low risk exposure, or by vaccination, influenced viral shedding and transmission on re-exposure.
[PLoS One]
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Severe Neonatal COVID-19: Challenges in Management and Therapeutic Approach

The authors reported a severe case of neonatal COVID-19 requiring intensive care and mechanical ventilation, further complicated by a multidrug resistant Enterobacter asburiae super-infection.
[Journal of Medical Virology]
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ACE2-Like Carboxypeptidase B38-CAP Protects from SARS-CoV-2-Induced Lung Injury

Researchers showed that B38-CAP, an ACE2-like enzyme, was protective against SARS-CoV-2-induced lung injury.
[Nature Communications]
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Immune System Cells from COVID-19 Patients Display Compromised Mitochondrial-Nuclear Expression Co-Regulation and Rewiring towards Glycolysis

Analysis of eight single-cells RNA-seq datasets from peripheral blood mononuclear cells, nasopharyngeal samples and Broncho alveolar lavage fluid, revealed significantly reduced mtDNA gene expression especially in immune system cells from patients.
[iScience]
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Nanometer-Resolution In Situ Structure of the SARS-CoV-2 Postfusion Spike Protein

By using cryo-electron tomography, investigators observed both prefusion and postfusion spikes in β-propiolactone–inactivated SARS-CoV-2 virions and solved the in situ structure of the postfusion spike at nanometer resolution.
[Proceedings of the National Academy of Sciences of the United States of America]
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Modeling Coronavirus Spike Protein Dynamics: Implications for Immunogenicity and Immune Escape

Investigators developed computational models for a large subset of S proteins associated with SARS-CoV-2, implemented through coarse-grained elastic network models and normal mode analysis.
[Biophysical Journal]
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An Aluminum Hydroxide:CpG Adjuvant Enhances Protection Elicited by a SARS-CoV-2 Receptor-Binding Domain Vaccine in Aged Mice

Investigators compared pattern recognition receptor agonists alone or formulated with aluminum hydroxide and benchmarked them against AS01B and AS03-like emulsion-based adjuvants for their potential to enhance receptor-binding domain immunogenicity in young and aged mice.
[Science Translational Medicine]
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Cross-Validation of SARS-CoV-2 Responses in Kidney Organoids and Clinical Populations

Scientists combined SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics.
[JCI Insight]
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Organ-Specific Genome Diversity of Replication-Competent SARS-CoV-2

Scientists reported a detailed virological analysis of 13 postmortem COVID-19 cases that provided proof of viremia and presence of replication-competent SARS-CoV-2 in extrapulmonary organs of immunocompromised patients, including heart, kidney, liver, and spleen.
[Nature Communications]
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