SARS-CoV-2

[Cell] Scientists analyzed human lymph nodes after infection or mRNA vaccination for correlates of serological differences.

[Proceedings of the National Academy of Sciences of the United States of America] The authors described the identification of vimentin, an intermediate filament protein widely expressed in cells of mesenchymal origin, as an important attachment factor for SARS-CoV-2 on human endothelial cells.

[Science Translational Medicine] The authors described AZD7442, a combination of two mAbs, AZD8895 and AZD1061, that simultaneously bound to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2.

[Science Immunology] Investigators measured neutralizing antibody responses from 104 vaccinated individuals, including those with breakthrough infections, hybrid immunity, and no infection history.

[Nature Aging] In cultured human cells or bronchial organoids, SASR-CoV-2 infection-induced senescent cells expressed high levels of a series of inflammatory factors known as senescence-associated secretory phenotypes 4 in a sustained manner, even after SARS-CoV-2 was no longer detectable.

[Annals of Neurology] Scientists investigated prospectively humoral and cellular responses to SARS-CoV-2 mRNA vaccination in 82 patients with neuroimmunologic disorders on anti-CD20 therapy and 82 age- and sex-matched healthy controls.