Hydroxychloroquine Use against SARS-CoV-2 Infection in Non-Human Primates

Investigators evaluated the antiviral activity of hydroxychloroquine (HCQ) both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in African green monkey kidney cells but not in a model of reconstituted human airway epithelium.
[Nature]
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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis Dependent Axis

Monocytes/macrophages were the most enriched immune cell types in the lungs of COVID-19 patients and appeared to have a central role in the pathogenicity of the disease.
[Cell Metabolism]
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Safety and Immunogenicity of the ChAdOx1 nCoV-19 Vaccine against SARS-CoV-2: A Preliminary Report of a Phase I/II, Single-Blind, Randomized Controlled Trial

Researchers conducted a Phase I/II, single-blind, randomized controlled trial in five trial sites in the UK of a chimpanzee adenovirus-vectored vaccine expressing the SARS-CoV-2 spike protein compared with a meningococcal conjugate vaccine as control.
[Lancet]
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COVID-19 and Cardiovascular Disease: From Basic Mechanisms to Clinical Perspectives

Pre-existing cardiovascular disease seems to be linked with worse outcomes and increased risk of death in patients with COVID-19, whereas COVID-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome and venous thromboembolism.
[Nature Reviews Cardiology]
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SARS-CoV-2 Failure to Infect or Replicate in Mosquitoes: An Extreme Challenge

Investigators provide the first experimental data to investigate the capacity of SARS-CoV-2 to infect and be transmitted by mosquitoes.
[Scientific Reports]
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A Literature Review of 2019 Novel Coronavirus (SARS-CoV2) Infection in Neonates and Children

The authors review all the current literature from 1 December 2019 to 7 May 2020 to provide useful information about SARS-CoV2 viral biology, epidemiology, diagnosis, clinical features, treatment, prevention, and hospital organization for clinicians dealing with this selected population.
[Pediatric Research]
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BioAegis Therapeutics Receives Approval to Proceed with Phase II Trial of its Gelsolin COVID-19 Treatment

BioAegis Therapeutics Inc. announces that it received regulatory clearance from The Spanish Agency for Medicines and Health Products for its Phase II Proof of Concept study of its lead product, recombinant human plasma gelsolin in hospitalized patients with severe COVID-19 pneumonia.
[BioAegis Therapeutics, Inc. (GlobeNewswire, Inc.)]
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Coronavirus Vaccine Data Are Targets for Foreign Hackers

A hacking group affiliated with the Russian government is targeting academic institutions and pharmaceutical companies worldwide to glean information on COVID-19 vaccine research, according to Western powers.
[The Scientist]
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SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked with Increased Morbidity and Mortality in Individuals with Diabetes

Upon entry into the host, this virus bound to the extracellular domain of angiotensin-I converting enzyme 2 (ACE2) in nasal, lung, and gut epithelial cells through its spike glycoprotein subunit S1.
[Diabetes]
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More than 150 Countries Sign Up for Global Vaccine Plan

More than 70 rich countries have signed up to a global coronavirus vaccine initiative intended to ensure that any effective shots are fairly distributed around the world- but which may also allow them to buy more vaccines to stockpile for their own citizens.
[Asssociated Press News]
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Once a Relic of Medical History, Radiation Emerges as an Intriguing — and Divisive — Treatment for COVID-19

Back in 2013, toxicologist Edward Calabrese and a colleague at the University of Massachusetts, Amherst, were combing over a cache of century-old data on low-dose radiation therapy, hunting for evidence on the scientific idea that small doses of certain poisons might actually be beneficial.
[STAT News]
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