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SARS-CoV-2

Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

[Journal of Cellular and Molecular Medicine] Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.

Landscape and Selection of Vaccine Epitopes in SARS-CoV-2

[Genome Medicine] The authors explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage.

Dynamic Innate Immune Response Determines Susceptibility to SARS-CoV-2 Infection and Early Replication Kinetics

[Journal of Experimental Medicine] Scientists examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids.

Multi-Omic Profiling Reveals Widespread Dysregulation of Innate Immunity and Hematopoiesis in COVID-19

[Journal of Experimental Medicine] Researchers performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases.

Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro

[Science Translational Medicine] To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.

Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Naïve and Recovered Individuals Following mRNA Vaccination

[Science Immunology] Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.

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