Tag results:
SARS-CoV-2
Pulmonary Cell News
Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity
[Journal of Cellular and Molecular Medicine] Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.
Immunology of Infectious Disease News
Landscape and Selection of Vaccine Epitopes in SARS-CoV-2
[Genome Medicine] The authors explored the set of computationally predicted SARS-CoV-2 HLA-I and HLA-II ligands, examining protein source, concurrent human/murine coverage, and population coverage.
Immunology of Infectious Disease News
Dynamic Innate Immune Response Determines Susceptibility to SARS-CoV-2 Infection and Early Replication Kinetics
[Journal of Experimental Medicine] Scientists examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids.
Immunology of Infectious Disease News
Multi-Omic Profiling Reveals Widespread Dysregulation of Innate Immunity and Hematopoiesis in COVID-19
[Journal of Experimental Medicine] Researchers performed multi-omic single-cell immune profiling of 64 COVID-19 patients across the full range of disease severity, from outpatients with mild disease to fatal cases.
Hematopoiesis News
Plasma from Patients with Bacterial Sepsis or Severe COVID-19 Induces Production of Suppressive Myeloid Cells from Human Hematopoietic Progenitor Cells In Vitro
[Science Translational Medicine] To examine the ontogeny and function of MS1 cells, scientists developed a cellular model for inducing CD14+ MS1 monocytes by treating human hematopoietic stem and progenitor cells from healthy bone marrow donors in culture with plasma from patients with severe bacterial infection or SARS-CoV-2 infection.
Immunology of Infectious Disease News
Distinct Antibody and Memory B Cell Responses in SARS-CoV-2 Naïve and Recovered Individuals Following mRNA Vaccination
[Science Immunology] Researchers showed that the SARS-CoV-2 envelope protein alone is able to cause acute respiratory distress syndrome-like damages in vitro and in vivo.