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SARS-CoV-2

SARS-CoV-2 Variants, Spike Mutations and Immune Escape

[Nature Reviews Microbiology] The authors summarize the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure, and discuss them in the context of observed mutation frequencies in global sequence datasets.

A Core-Shell Structured COVID-19 mRNA Vaccine with Favorable Biodistribution Pattern and Promising Immunity

[Signal Transduction and Targeted Therapy] Scientists reported on the development of a highly efficacious mRNA vaccine, SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core–shell structured lipopolyplex nanoparticles.

Dynamic Causal Modelling of Immune Heterogeneity

[Scientific Reports] Researchers introduced a model of the immune response to a virus. This was based upon the same sort of mean-field dynamics as used in epidemiology. However, in place of the location, clinical status, and other attributes of people in an epidemiological model, researchers considered the state of a virus, B and T-lymphocytes, and the antibodies they generated.

Translational Shutdown and Evasion of the Innate Immune Response by SARS-CoV-2 NSP14 Protein

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that the translation inhibition activity of NSP14 was conserved in human coronaviruses. NSP14 was required for virus replication through contribution of its exoribonuclease and N7-methyltransferase activities.

Peripheral and Lung Resident Memory T Cell Responses against SARS-CoV-2

[Nature Communications] Reesarchers highlighted a balanced anti-inflammatory antiviral response associated with a better outcome and persisting TRM cells as important for future protection against SARS-CoV-2 infection.

Viral Fibrotic Scoring and Drug Screen Based on MAPK Activity Uncovers EGFR as a Key Regulator of COVID-19 Fibrosis

[Scientific Reports] Researchers clustered 277 cell lines and revealed distinct COVID-19 transcriptomic signatures of the cells with similar phenotypes that defines their suitability for COVID-19 research.

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