Telomere Length and Human Hippocampal Neurogenesis

The authors modeled telomere shortening in human hippocampal progenitor cells in vitro using a serial passaging protocol that mimicked the end-replication problem.
[Neuropsychopharmacology]
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

The Potential of Induced Pluripotent Stem Cells for Discriminating Neurodevelopmental Disorders

Scientists review the current knowledge on iPSC models for schizophrenia and autism spectrum disorders with emphasis on the discrimination between them.
[Stem Cells Translational Medicine]
Stock, R., Jeckel, P., Kraushaar, U., Wüst, R., Fallgatter, A., & Volkmer, H. (n.d.). The potential of induced pluripotent stem cells for discriminating neurodevelopmental disorders. STEM CELLS Translational Medicine, n/a(n/a). https://doi.org/10.1002/sctm.20-0206 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Mesenchymal Stem Cells Derived Extracellular Vesicles Improve Behavioral and Biochemical Deficits in a Phencyclidine Model of Schizophrenia

Researchers assessed the feasibility of intranasal delivery of mesenchymal stem cell-derived-extracellular vesicles to alleviate schizophrenia-like behaviors in a phencylidine model of schizophrenia.
[Translational Psychiatry]
Full Article
Bookmark

No account yet? Register

0
Share

Cognitive Impact of Neuronal Antibodies: Encephalitis and Beyond

Investigators describe the cognitive impairment associated with each antibody-mediated syndrome and, using evidence from imaging and animal studies, examined how the nature of the impairment related to the underlying neuroimmunological and receptor-based mechanisms.
[Translational Psychiatry]
Full Article
Bookmark

No account yet? Register

0
Share

Developmental Excitation-Inhibition Imbalance Underlying Psychoses Revealed by Single-Cell Analyses of Discordant Twins-Derived Cerebral Organoids

Brain organoids derived from iPSCs of patients are a powerful avenue to investigate the pathophysiological processes. Scientists generated iPSC-derived cerebral organoids from monozygotic twins discordant for psychosis.
[Molecular Psychiatry]
Sawada, T., Chater, T. E., Sasagawa, Y., Yoshimura, M., Fujimori-Tonou, N., Tanaka, K., Benjamin, K. J. M., Paquola, A. C. M., Erwin, J. A., Goda, Y., Nikaido, I., & Kato, T. (2020). Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids. Molecular Psychiatry, 1–17. https://doi.org/10.1038/s41380-020-0844-z Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share