Otsuka and Lundbeck Announce FDA Acceptance of Supplemental New Drug Application; Receive Priority Review for Treatment of Schizophrenia in Adolescents

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S reported that the US FDA has accepted a Supplemental New Drug Application for the treatment of schizophrenia in adolescents with Rexulti® and has granted Otsuka and Lundbeck Priority Review.
[Otsuka Pharmaceutical Co., Ltd. (BusinessWire, Inc.)]
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Mechanisms Governing Activity-Dependent Synaptic Pruning in the Developing Mammalian CNS

Researchers discuss how developmental pruning programs may go awry in neurodevelopmental disorders of the human CNS, focusing on autism spectrum disorder and schizophrenia.
[Nature Reviews Neuroscience]
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Teva and MedinCell Announce FDA Acceptance of New Drug Application for TV-46000/Mdc-IRM as a Treatment for Patients with Schizophrenia

Teva Pharmaceuticals, and MedinCell announced that the New Drug Application for TV-46000/mdc-IRM for the treatment of schizophrenia has been accepted by the US FDA
[Teva Pharmaceuticals, Ltd. (BusinessWire, Inc.)]
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BDNF Controls GABAAR Trafficking and Related Cognitive Processes via Autophagic Regulation of p62

Researchers show that reduced BDNF and GABA also co-occur with attenuated autophagy in human depression.
[Neuropsychopharmacology]
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Implication of Human Endogenous Retrovirus W Family Envelope in Hepatocellular Carcinoma Promotes MEK/ERK-Mediated Metastatic Invasiveness and Doxorubicin Resistance

There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.
[Cell Death Discovery]
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Involvement of Vascular Endothelial Growth Factor in Schizophrenia

Scientists analyze the literature data concerning the role of vascular endothelial growth factor in modulating the angiogenic response in Schizophrenia.
[Neuroscience Letters]
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Translational Evidence for Lithium-Induced Brain Plasticity and Neuroprotection in the Treatment of Neuropsychiatric Disorders

The authors focus on neural adaptations that may underlie psychostimulant-induced psychotic development and to dissect, through the sensitization process, which features are shared in bipolar disorder and other psychiatric disorders, including schizophrenia.
[Translational Psychiatry]
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Neuronal and Glial 3D Chromatin Architecture Informs the Cellular Etiology of Brain Disorders

Scientists integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.
[Nature Communications]
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Dysregulation of Brain and Choroid Plexus Cell Types in Severe COVID-19

Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease4–6.
[Nature]
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Atypical Antipsychotic Olanzapine Inhibits Voltage-Dependent K+ Channels in Coronary Arterial Smooth Muscle Cells

Electrophysiological recordings were performed in freshly isolated coronary arterial smooth muscle cells to investigate the inhibitory effect of olanzapine on voltage-dependent K+ channels.
[Pharmacological Reports]
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Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons

Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.
[Proceedings of the National Academy of Sciences of the United States of America]
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