Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S reported that the US FDA has accepted a Supplemental New Drug Application for the treatment of schizophrenia in adolescents with Rexulti® and has granted Otsuka and Lundbeck Priority Review.
[Otsuka Pharmaceutical Co., Ltd. (BusinessWire, Inc.)]
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Researchers discuss how developmental pruning programs may go awry in neurodevelopmental disorders of the human CNS, focusing on autism spectrum disorder and schizophrenia.
[Nature Reviews Neuroscience]
[zotpress userid=” items=’ZJZVAVUE’ style=’apa’ cite=’yes’]
Teva Pharmaceuticals, and MedinCell announced that the New Drug Application for TV-46000/mdc-IRM for the treatment of schizophrenia has been accepted by the US FDA
[Teva Pharmaceuticals, Ltd. (BusinessWire, Inc.)]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Researchers show that reduced BDNF and GABA also co-occur with attenuated autophagy in human depression.
[zotpress userid=” items=’ZHNSWT43′ style=’apa’ cite=’yes’]
There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.
[Cell Death Discovery]
[zotpress userid=” items=’F74E85JR’ style=’apa’ cite=’yes’]
Scientists analyze the literature data concerning the role of vascular endothelial growth factor in modulating the angiogenic response in Schizophrenia.
[zotpress userid=’6445218′ items=’5J5UVAMK’ style=’apa’ cite=’yes’]
The authors focus on neural adaptations that may underlie psychostimulant-induced psychotic development and to dissect, through the sensitization process, which features are shared in bipolar disorder and other psychiatric disorders, including schizophrenia.
[zotpress userid=’7753456′ items=’FENUJ5MM’ style=’apa’ cite=’yes’]
Scientists integrated genome-wide chromosome conformation data from purified neurons and glia with transcriptomic and enhancer profiles, to characterize the gene regulatory landscape of two major cell classes in the human brain.
[zotpress userid=’7753456′ items=’RXGK36U3′ style=’apa’ cite=’yes’]
Scientists discovered COVID-19 disease-associated microglia and astrocyte subpopulations that share features with pathological cell states reported in human neurodegenerative disease4–6.
[zotpress userid=’7753456′ items=’7M2M4BGV’ style=’apa’ cite=’yes’]
Electrophysiological recordings were performed in freshly isolated coronary arterial smooth muscle cells to investigate the inhibitory effect of olanzapine on voltage-dependent K+ channels.
[zotpress userid=’7992332′ items=’S85R4VPV’ style=’apa’ cite=’yes’]
Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=’7753456′ items=’IKPIR4UB’ style=’apa’ cite=’yes’]