schizophrenia

[Molecular Psychiatry] Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.

[Science Advances] The authors demonstrated that a high-sucrose diet during adolescence induced psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for glyoxalase-1, an enzyme involved in detoxification of sucrose metabolites.

[Molecular Psychiatry] Scientists review the existing experimental and translational research pinpointing the complex dynamics of oxidative stress mechanisms and their modulation in relation to schizophrenia pathophysiology.

[Translational Psychiatry] Investigators used a human induced pluripotent stem cell (iPSC)-derived astrocyte model and investigated the temporal patterns of astroglia differentiation during developmental stages critical for schizophrenia using RNA sequencing.

[Boehringer Ingelheim] Boehringer Ingelheim and the Institute of Psychiatry, Psychology & Neuroscience at King’s College London announced a new collaboration focused on understanding the malfunctions in brain circuits that drive impaired cognition in people with major depressive disorder and schizophrenia.

[Translational Psychiatry] Researchers generated iPSCs from patients with familial schizophrenia, differentiated these cells into neurons, and investigated the molecular and cellular phenotypes of the patient’s neurons.