single-cell RNA sequencing

[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.

[Signal Transduction and Targeted Therapy] Researchers established a multi-omics atlas, integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing. They investigated their differences in genetic amplification, cellular compositions, and expression modules.

[Stem Cell Reports] The authors stably induced retinal pigment epithelium-like cells from human fibroblasts by conditional overexpression of both broad plasticity and lineage-specific transcription factors.

[iScience] Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.

[Oncogene] Investigators used proteomics and single cell RNA-sequencing analysis to examine the cancer-associated fibroblast landscape in hepatocellular carcinoma.

[Nature Communications] Researchers uncovered heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that were enriched in prostate cancer and identified a population of tumor-associated club cells that may be associated with prostate carcinogenesis.