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single-cell RNA sequencing

Neutrophils Direct Preexisting Matrix to Initiate Repair in Damaged Tissues

[Nature Immunology] By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, scientists showed that preexisting matrix was transferred across organs into wounds in various injury models.

Mice Infected with Mycobacterium tuberculosis Are Resistant to Acute Disease Caused by Secondary Infection with SARS-CoV-2

[PLoS Pathogens] In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.

Engineering a Niche Supporting Hematopoietic Stem Cell Development Using Integrated Single-Cell Transcriptomics

[Nature Communications] To identify the signals responsible for HSC formation, scientists used single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of aorta-gonad-mesonephros region-derived cells transitioning from hemogenic endothelium to HSCs,

Ly49E Separates Liver ILC1s into Embryo-Derived and Postnatal Subsets with Different Functions

[Journal of Experimental Medicine] Genetic fate-mapping analysis revealed that liver Ly49E+ ILC1s with strong cytotoxicity originated from embryonic non–bone marrow hematopoietic progenitor cells, persisted locally during postnatal life, and mediated protective immunity against cytomegalovirus infection in newborn mice.

Human Forebrain Organoids Reveal Connections between Valproic Acid Exposure and Autism Risk

[Translational Psychiatry] Scientists used human forebrain organoids, in vitro derived 3D cell cultures that recapitulated key human brain developmental features.

Cellular Heterogeneity and Transcriptomic Profiles during Intrahepatic Cholangiocarcinoma Initiation and Progression

[Hepatology] Researchers performed single-cell RNA-sequencing using AKT/NICD-induced mouse intrahepatic cholangiocarcinoma tissues at early, middle, and late stages.

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