single-cell RNA sequencing

[Science Translational Medicine] Scientists investigated the potential role of adipogenesis by dermal fibroblasts in acne and performed single-cell RNA sequencing on human acne lesions and mouse skin challenged by Cutibacterium acnes.

[Experimental Dermatology] The authors discuss the available technologies and technical considerations of single-cell RNA sequencing and describes its applications to a broad spectrum of dermatological diseases.

[Acta Pharmacologica Sinica] In vivo muscle contractile properties recovery in mice ischemic lower limbs following gliflozins treatment was evaluated. The C2C12 myoblast differentiation after gliflozins treatment was also assessed in vitro.

[Signal Transduction and Targeted Therapy] Scientists indicated that targeting IL6/JAK2/STAT3 signaling in activated microglia might be a promising new approach for inhibiting brain metastasis in NSCLC patients.

[Science Advances] Investigators developed a system for the production of platelet precursor cells, megakaryocytes, from PSCs. These cultures could be maintained for greater than 100 days, implying culture renewal by megakaryocyte progenitors.

[NPJ Regenerative Medicine] Scientists provide an overview of the composition and importance of the muscle stem cell microenvironment, and discuss relevant ECM proteins and how their mutations or dysregulation impact young and aged muscle tissue or contribute to diseases.