skeletal muscle cells

[Cellular and Molecular Life Sciences] Researchers developed a multifactor-based protocol that combined adenovector-mediated MYOD expression, small molecule inhibitor and growth factor treatment, and electrical pulse stimulation to efficiently reprogram different types of human-derived multipotent stem cells into physiologically functional skeletal muscle cells.

[Experimental Cell Research] The authors found that lipid transport-associated genes were upregulated in the high interleukin-6 (IL-6) receptor expression group. IL-6 promoted fatty acid uptake in both AML cell lines and primary AML cells.

[Acta Pharmacologica Sinica] Researchers investigated whether sotagliflozin, an anti-hyperglycemia SGLT2 inhibitor, exerted therapeutic angiogenesis effects in diabetic HLI in vitro and in vivo.

[BMC Genomics] RGMa expression patterns and signaling pathways via Neogenin and/or as BMP coreceptors indicated that this axon guidance molecule could also be working in other processes and diseases, including during myogenesis.

[Acta Biomaterialia] Researchers proposed an in situ-crosslinking gellan gum-based hydrogel tethered with a skeletal muscle-inspired laminin-derived peptide RKRLQVQLSIRTC(Q) and encapsulated with skeletal muscle cells.

[Cell Biochemistry and Biophysics] The authors investigated the effect of fatty acid binding protein 4 (FABP4) on lipogenesis in human skeletal muscle cells stimulated by Interleukin-4 and explored the mechanistic basis.