Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Investigators showed that berberine administration markedly ameliorated intralipid-induced insulin resistance without affecting blood glucose. They used human skeletal muscle cells, hepatocytes, human umbilical vein endothelial cells, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes

The authors investigated the role of vitamin D in myogenesis and muscle fiber maintenance in an immortalized mouse myogenic cell line.
[Nutrients]
Hosoyama, T., Iida, H., Kawai-Takaishi, M., & Watanabe, K. (2020). Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes. Nutrients, 12(8), 2192. https://doi.org/10.3390/nu12082192 Cite
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Loss of HDAC11 Accelerates Skeletal Muscle Regeneration

Scientists investigated for the first time the consequences of HDAC11 genetic impairment on skeletal muscle regeneration, a process principally dependent on its resident stem cells in coordination with infiltrating immune cells and stromal cells.
[FEBS Journal]
Núñez‐Álvarez, Y., Hurtado, E., Muñoz, M., García‐Tuñon, I., Rech, G. E., Pluvinet, R., Sumoy, L., Pendás, A. M., Peinado, M. A., & Suelves, M. (n.d.). Loss of HDAC11 accelerates skeletal muscle regeneration. The FEBS Journal, n/a(n/a). https://doi.org/10.1111/febs.15468 Cite
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Metabolomic Analysis of Primary Human Skeletal Muscle Cells during Myogenic Progression

Scientists built a comprehensive profile of metabolites in primary human skeletal muscle cells during myogenic progression in an untargeted metabolomics approach using a high resolution Orbitrap Fusion Tribrid Mass Spectrometer.
[Scientific Reports]
Kumar, A., Kumar, Y., Sevak, J. K., Kumar, S., Kumar, N., & Gopinath, S. D. (2020). Metabolomic analysis of primary human skeletal muscle cells during myogenic progression. Scientific Reports, 10(1), 11824. https://doi.org/10.1038/s41598-020-68796-4 Cite
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Gene Expression Profile of Adhesion and Extracellular Matrix Molecules during Early Stages of Skeletal Muscle Regeneration

After day five, as myoblast migration and differentiation started, genes for basement membrane constituents were found down-regulated, whereas genes for extracellular matrix molecules, macrophage, myoblast adhesion, and migration receptors were up-regulated.
[Journal of Cellular and Molecular Medicine]
Ceafalan, L. C., Dobre, M., Milanesi, E., Niculae, A. M., Manole, E., Gherghiceanu, M., & Hinescu, M. E. (n.d.). Gene expression profile of adhesion and extracellular matrix molecules during early stages of skeletal muscle regeneration. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15624 Cite
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Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

In Dog and Human, the authors described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]

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Myeloid ALX/FPR2 Regulates Vascularization Following Tissue Injury

Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.
[Proceedings of the National Academy of Sciences of the United States of America]
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Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-Muscle Myosin II Assembly and Function in Migrating Cells

In cells, phosphorylation of Y155, or its phospho-mimetic mutation, prevented the interaction of regulatory light chain with the myosin heavy chain to form functional non-muscle myosin II units.
[Current Biology]
Aguilar-Cuenca, R., Llorente-González, C., Chapman, J. R., Talayero, V. C., Garrido-Casado, M., Delgado-Arévalo, C., Millán-Salanova, M., Shabanowitz, J., Hunt, D. F., Sellers, J. R., Heissler, S. M., & Vicente-Manzanares, M. (2020). Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells. Current Biology, 0(0). https://doi.org/10.1016/j.cub.2020.04.057 Cite
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Innervation: The Missing Link for Biofabricated Tissues and Organs

The authors assert that innervation should be included as a necessary component for tissue and organ biofabrication, and that strategies to orchestrate host axonal integration are advantageous to ensure proper function, tolerance, assimilation, and bio-regulation with the recipient post-implant.
[NPJ Regenerative Medicine]
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