Substrate Utilization of Cultured Skeletal Muscle Cells in Patients with CFS

The authors outline experiments looking at the utilization of different substrates by skeletal muscle cells from chronic fatigue syndrome patients and healthy controls using extracellular flux analysis.
[Scientific Reports]
Tomas, C., Elson, J. L., Newton, J. L., & Walker, M. (2020). Substrate utilisation of cultured skeletal muscle cells in patients with CFS. Scientific Reports, 10(1), 18232. https://doi.org/10.1038/s41598-020-75406-w Cite
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ActivinA Activates Notch1-Shh Signaling to Regulate Proliferation in C2C12 Skeletal Muscle Cells

Scientists determined the physiological functions of Activin A, Notch and Sonic Hedgehog signaling in the proliferation of mouse C2C12 myoblasts and to explore their interactions.
[Molecular and Cellular Endocrinology]
Ma, L., Li, C., Lian, S., Xu, B., Yuan, J., Lu, J., Yang, H., Guo, J., & Ji, H. (2021). ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells. Molecular and Cellular Endocrinology, 519, 111055. https://doi.org/10.1016/j.mce.2020.111055 Cite
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Differential Effects of Right and Left Heart Failure on Skeletal Muscle in Rats

Scientists compared skeletal muscle sarcopenia in a novel two‐stage model of right ventricular failure to an established model of left ventricular failure.
[Journal of Cachexia Sarcopenia and Muscle]
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SWELL1 Regulates Skeletal Muscle Cell Size, Intracellular Signalling, Adiposity and Glucose Metabolism

Researchers showed that SWELL1 functionally encodes a swell-activated anion channel that regulates PI3K-AKT, ERK1/2, mTOR signaling, muscle differentiation, myoblast fusion, cellular oxygen consumption, and glycolysis in skeletal muscle cells.
[eLife]
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Changes in Skeletal Muscle Diffusion Parameters Owing to Intramyocellular Lipid

Investigators assumed that the hybrid training promoted metabolism of the whole skeletal muscle including lipids, which reduced the amount of intramyocellular lipid, and led to a secondary enlargement of the diffusion space in the skeletal muscle cells.
[Magnetic Resonance Imaging]
Tadano, K., Okamoto, Y., Isobe, T., Mori, S., Suzuki, H., Minami, M., & Sakae, T. (2020). Changes in skeletal muscle diffusion parameters owing to intramyocellular lipid. Magnetic Resonance Imaging. https://doi.org/10.1016/j.mri.2020.08.002 Cite
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Berberine Improves Intralipid-Induced Insulin Resistance in Murine

Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
Dong, Z., Lin, H., Chen, F., Che, X., Bi, W., Shi, S., Wang, J., Gao, L., He, Z., & Zhao, J. (2020). Berberine improves intralipid-induced insulin resistance in murine. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-0493-4 Cite
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Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes

The authors investigated the role of vitamin D in myogenesis and muscle fiber maintenance in an immortalized mouse myogenic cell line.
[Nutrients]
Hosoyama, T., Iida, H., Kawai-Takaishi, M., & Watanabe, K. (2020). Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes. Nutrients, 12(8), 2192. https://doi.org/10.3390/nu12082192 Cite
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Loss of HDAC11 Accelerates Skeletal Muscle Regeneration

Scientists investigated for the first time the consequences of HDAC11 genetic impairment on skeletal muscle regeneration, a process principally dependent on its resident stem cells in coordination with infiltrating immune cells and stromal cells.
[FEBS Journal]
Núñez‐Álvarez, Y., Hurtado, E., Muñoz, M., García‐Tuñon, I., Rech, G. E., Pluvinet, R., Sumoy, L., Pendás, A. M., Peinado, M. A., & Suelves, M. (n.d.). Loss of HDAC11 accelerates skeletal muscle regeneration. The FEBS Journal, n/a(n/a). https://doi.org/10.1111/febs.15468 Cite
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Metabolomic Analysis of Primary Human Skeletal Muscle Cells during Myogenic Progression

Scientists built a comprehensive profile of metabolites in primary human skeletal muscle cells during myogenic progression in an untargeted metabolomics approach using a high resolution Orbitrap Fusion Tribrid Mass Spectrometer.
[Scientific Reports]
Kumar, A., Kumar, Y., Sevak, J. K., Kumar, S., Kumar, N., & Gopinath, S. D. (2020). Metabolomic analysis of primary human skeletal muscle cells during myogenic progression. Scientific Reports, 10(1), 11824. https://doi.org/10.1038/s41598-020-68796-4 Cite
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Gene Expression Profile of Adhesion and Extracellular Matrix Molecules during Early Stages of Skeletal Muscle Regeneration

After day five, as myoblast migration and differentiation started, genes for basement membrane constituents were found down-regulated, whereas genes for extracellular matrix molecules, macrophage, myoblast adhesion, and migration receptors were up-regulated.
[Journal of Cellular and Molecular Medicine]
Ceafalan, L. C., Dobre, M., Milanesi, E., Niculae, A. M., Manole, E., Gherghiceanu, M., & Hinescu, M. E. (n.d.). Gene expression profile of adhesion and extracellular matrix molecules during early stages of skeletal muscle regeneration. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15624 Cite
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Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function hMuStem Cells Preserve Function of Infarcted Heart

In Dog and Human, the authors described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits.
[Molecular Therapy-Methods & Clinical Development]
Human MuStem cell grafting into infarcted rat heart attenuates adverse tissue remodeling and preserves cardiac function hMuStem cells preserve function of infarcted heart: Molecular Therapy - Methods & Clinical Development. (n.d.). Retrieved June 16, 2020, from https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(20)30133-9 Cite

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