smooth muscle cells

[Colloids and Surfaces B-Biointerfaces] Researchers constructed hydrogel substrates with the stiffness of 18–86 kPa to explore the effect of physiological stiffness on vascular cells.

[Scientific Reports] The authors investigated whether local delivery of adeno-associated viral (AAV) vectors expressing oxidation-resistant wild type apolipoprotein A1 (apoA1) preserved apoA1 functionality.

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

[Cell Death & Disease] The authors investigated the mechanism of bone marrow MSC-derived exosome using high phosphate stimulated human aortic smooth muscle cells and 5/6 subtotal nephrectomy rat models.

[iScience] Scientists unraveled the substantial contribution of miRNAs in regulating the smooth muscle cell (SMC) transcriptome and identified the miR-200 cluster as a pro-quiescence mechanism and a potential inhibitor of vascular restenosis.

[Ebiomedicine] Sodium thiosulfate, a drug used for the treatment of cyanide poisoning and calciphylaxis, protected against intimal hyperplasia in a mouse model of arterial restenosis and in human vein segments.