CD276 Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

The authors showed that cancer stem cells upregulated the immune checkpoint molecule CD276 to evade host immune responses.
[Cell Stem Cell]
Wang, C., Li, Y., Jia, L., Kim, J. koo, Li, J., Deng, P., Zhang, W., Krebsbach, P. H., & Wang, C.-Y. (2021). CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2021.04.011 Cite
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Comprehensive Analysis of DNA Damage Repair in Squamous Cell Carcinoma Subtypes

Investigators characterized the molecular profile of squamous cell carcinoma by developing a classification system based on DNA damage repair gene expression profiles.
[Life Sciences]
Comprehensive analysis of DNA damage repair in squamous cell carcinoma subtypes. (2021). Life Sciences, 278, 119559. https://doi.org/10.1016/j.lfs.2021.119559 Cite
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Onconova Announced First Patient Dosed in Investigator-Initiated Phase II Study of Rigosertib in Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma

Onconova Therapeutics, Inc., announced that the first patient has been dosed in an investigator-initiated Phase II study to assess the efficacy and safety of rigosertib in patients with recessive dystrophic epidermolysis bullosa-associated locally advanced/metastatic squamous cell carcinoma.
[Onconova Therapeutics, Inc. (GLOBE NEWSWIRE)]
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HEATR1, a Novel Interactor of Pontin/Reptin, Stabilizes Pontin/Reptin and Promotes Cell Proliferation of Oral Squamous Cell Carcinoma

Researchers identified HEAT repeat-containing protein 1 (HEATR1) as a novel binding factor of Pontin/Reptin.
[Biochemical and Biophysical Research Communications]
HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma. (2021). Biochemical and Biophysical Research Communications, 557, 294–301. https://doi.org/10.1016/j.bbrc.2021.04.021 Cite
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CD44v6-Targeted CAR T-cells Specifically Eliminate CD44 Isoform 6 Expressing Head/Neck Squamous Cell Carcinoma Cells

Scientists established a highly specific chimeric antigen receptors (CAR) against CD44v6 on head and neck squamous cell carcinoma cells that can be expressed on normal T-cells with lentiviral vectors.
[Oral Oncology]
CD44v6-targeted CAR T-cells specifically eliminate CD44 isoform 6 expressing head/neck squamous cell carcinoma cells. (2021). Oral Oncology, 116, 105259. https://doi.org/10.1016/j.oraloncology.2021.105259 Cite
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Prion Protein Is Associated with a Worse Prognosis of Head and Neck Squamous Cell Carcinoma

Scientists investigated hypoxia’s effect in lymph node metastasis by prion protein expression changes and its main partners.
[Journal of Oral Pathology & Medicine]
Santos, E. M., Fraga, C. A. de C., Xavier, A. R. E. de O., Xavier, M. A. de S., Souza, M. G., Jesus, S. F. de, Paula, A. M. B. de, Farias, L. C., Santos, S. H. S., Santos, T. G., Beraldo, F. H., & Guimarães, A. L. S. (n.d.). Prion protein is associated with a worse prognosis of head and neck squamous cell carcinoma. Journal of Oral Pathology & Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jop.13188 Cite
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Downregulated hsa_circ_0036988 Promotes Proliferation and Metastasis in Oral Squamous Cell Carcinoma

The study investigated the potential function of a candidate circRNA hsa_circ_0036988 in oral squamous cell carcinoma
[Cancer Biomarkers]
Zhang, H., Zhang, B., Zhang, Y., Qian, M., Shen, Y., & Yang, H. (2021). Downregulated hsa_circ_0036988 promotes proliferation and metastasis in oral squamous cell carcinoma. Cancer Biomarkers, Preprint(Preprint), 1–9. https://doi.org/10.3233/CBM-210082 Cite
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Exploring the Dermotoxicity of the Mycotoxin Deoxynivalenol: Combined Morphologic and Proteomic Profiling of Human Epidermal Cells Reveals Alteration of Lipid Biosynthesis Machinery and Membrane Structural Integrity Relevant for Skin Barrier Function

To investigate the potential dermotoxicity of Deoxynivalenol (DON), epidermoid squamous cell carcinoma cells A431 were compared to primary human neonatal keratinocytes (HEKn) cells via proteome/phosphoproteome profiling.
[Archives of Toxicology]
Del Favero, G., Janker, L., Neuditschko, B., Hohenbichler, J., Kiss, E., Woelflingseder, L., Gerner, C., & Marko, D. (2021). Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. Archives of Toxicology. https://doi.org/10.1007/s00204-021-03042-y Cite
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Disruption of the HER3-PI3K-mTOR Oncogenic Signaling Axis and PD-1 Blockade as a Multimodal Precision Immunotherapy in Head and Neck Cancer

The authors employed an unbiased kinome-wide siRNA screen to reveal that HER3, was essential for the proliferation of most HNSCC cells that did not harbor PIK3CA mutations.
[Nature Communications]
Wang, Z., Goto, Y., Allevato, M. M., Wu, V. H., Saddawi-Konefka, R., Gilardi, M., Alvarado, D., Yung, B. S., O’Farrell, A., Molinolo, A. A., Duvvuri, U., Grandis, J. R., Califano, J. A., Cohen, E. E. W., & Gutkind, J. S. (2021). Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer. Nature Communications, 12(1), 2383. https://doi.org/10.1038/s41467-021-22619-w Cite
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Propofol Inhibits Tumor Angiogenesis through Targeting VEGF/VEGFR and mTOR/eIF4E Signaling

Investigators showed that propofol inhibited tubular structure formation of both lung cancer associated endothelial cells and colon cancer associated endothelial cells, particularly the early stages of angiogenesis.
[Biochemical and Biophysical Research Communications]
Wang, Z., Cao, B., Ji, P., & Yao, F. (2021). Propofol inhibits tumor angiogenesis through targeting VEGF/VEGFR and mTOR/eIF4E signaling. Biochemical and Biophysical Research Communications, 555, 13–18. https://doi.org/10.1016/j.bbrc.2021.03.094 Cite
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Female Immunity Protects from Cutaneous Squamous Cell Carcinoma

Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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