Pentraxin 3 Acts as a Functional Effector of Akt/NF-κB Signaling to Modulate the Progression and Cisplatin-Resistance in Non-Small Cell Lung Cancer

The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.
[Archives of Biochemistry and Biophysics]
Li, Y., Song, X., Niu, J., Ren, M., Tang, G., Sun, Z., & Kong, F. (2021). Pentraxin 3 acts as a functional effector of Akt/NF-κB signaling to modulate the progression and cisplatin-resistance in non-small cell lung cancer. Archives of Biochemistry and Biophysics, 108818. https://doi.org/10.1016/j.abb.2021.108818 Cite
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A Unique Subset of Glycolytic Tumor-Propagating Cells Drives Squamous Cell Carcinoma

The authors showed that the NAD+-dependent histone deacetylase sirtuin 6 was a robust tumor suppressor in head and neck squamous cell carcinoma, acting as a modulator of glycolysis in these tumors.
[Nature Metabolism]
Choi, J.-E., Sebastian, C., Ferrer, C. M., Lewis, C. A., Sade-Feldman, M., LaSalle, T., Gonye, A., Lopez, B. G. C., Abdelmoula, W. M., Regan, M. S., Cetinbas, M., Pascual, G., Wojtkiewicz, G. R., Silveira, G. G., Boon, R., Ross, K. N., Tirosh, I., Saladi, S. V., Ellisen, L. W., … Mostoslavsky, R. (2021). A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nature Metabolism, 3(2), 182–195. https://doi.org/10.1038/s42255-021-00350-6 Cite
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Neoadjuvant Anti-OX40 (MEDI6469) Therapy in Patients with Head and Neck Squamous Cell Carcinoma Activates and Expands Antigen-Specific Tumor-Infiltrating T Cell

Scientists describe the results from a Phase Ib clinical trial in which 17 patients with locally advanced head and neck squamous cell carcinoma received a murine anti-human OX40 agonist antibody prior to definitive surgical resection.
[Nature Communications]
Duhen, R., Ballesteros-Merino, C., Frye, A. K., Tran, E., Rajamanickam, V., Chang, S.-C., Koguchi, Y., Bifulco, C. B., Bernard, B., Leidner, R. S., Curti, B. D., Fox, B. A., Urba, W. J., Bell, R. B., & Weinberg, A. D. (2021). Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells. Nature Communications, 12(1), 1047. https://doi.org/10.1038/s41467-021-21383-1 Cite
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Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA

Scientists evaluated the association of radiation response of cervical CSCs with clinical and morphological parameters of disease and features of human papillomavirus (HPV) infection.
[International Journal of Molecular Sciences]
Zamulaeva, I., Selivanova, E., Matchuk, O., Kiseleva, V., Mkrtchyan, L., & Krikunova, L. (2021). Radiation Response of Cervical Cancer Stem Cells Is Associated with Pretreatment Proportion of These Cells and Physical Status of HPV DNA. International Journal of Molecular Sciences, 22(3), 1445. https://doi.org/10.3390/ijms22031445 Cite
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Elevated NSD3 Histone Methylation Activity Drives Squamous Cell Lung Cancer

Researchers identified the histone H3 lysine 36 methyltransferase NSD3, the gene for which is located in the 8p11–12 amplicon, as a key regulator of lung squamous cell carcinoma tumorigenesis.
[Nature]
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Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System

The authors investigated the expression of components of the renin-angiotensin system by CSC subpopulations in metastatic head and neck cutaneous squamous cell carcinoma.
[Cells]
Siljee, S., Buchanan, O., Brasch, H. D., Bockett, N., Patel, J., Paterson, E., Purdie, G. L., Davis, P. F., Itinteang, T., & Tan, S. T. (2021). Cancer Stem Cells in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma Express Components of the Renin-Angiotensin System. Cells, 10(2), 243. https://doi.org/10.3390/cells10020243 Cite
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Tumor Microenvironment and Immune-Related Therapies of Head and Neck Squamous Cell Carcinoma

Investigators discuss classical head and neck squamous cell carcinoma immunotherapy, and highlight examples of clinical trials using CTLA-4 inhibitors and PD-1/PD-L1 related combination therapies.
[Molecular Therapy-Oncolytics]
Qin, Y., Zheng, X., Gao, W., Wang, B., & Wu, Y. (2021). Tumor microenvironment and immune-related therapies of Head and neck squamous cell carcinoma. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2021.01.011 Cite
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The Anti-Skin Squamous Cell Carcinoma Cell Activity by the SphK1-Targeting microRNA-6784

The authors identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). They showed that miR-6784 was located at the cytoplasm of A431 skin squamous cell carcinoma cells.
[Aging]
Aging | The anti-skin squamous cell carcinoma cell activity by the SphK1-targeting microRNA-6784 - Full Text. (n.d.). Retrieved January 22, 2021, from https://www.aging-us.com/article/202336/text Cite
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Rab11-FIP1 Mediates Epithelial-Mesenchymal Transition and Invasion in Esophageal Cancer

In 3D organoid models, genetic knockdown of Rab11‐FIP1 resulted in increased organoid size. Loss of Rab11‐FIP1 increased tumor cell invasion in part through mutant p53 but also in an independent manner.
[EMBO Reports]
Tang, Q., Lento, A., Suzuki, K., Efe, G., Karakasheva, T., Long, A., Giroux, V., Islam, M., Wileyto, E. P., Klein-Szanto, A. J., Nakagawa, H., Bass, A., & Rustgi, A. K. (2021). Rab11-FIP1 mediates epithelial-mesenchymal transition and invasion in esophageal cancer. EMBO Reports, n/a(n/a), e48351. https://doi.org/10.15252/embr.201948351 Cite
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Nektar Therapeutics Announces Dosing of First Patients in Phase I/II Study of its IL-15 Agonist, NKTR-255, in Combination with Cetuximab in Patients with Head and Neck Squamous Cell Carcinoma or Colorectal Cancer

Nektar Therapeutics announced that the first patient has been dosed in the Phase I/II trial of NKTR-255, Nektar’s investigational IL-15 pathway agonist, in patients with relapsed or refractory head and neck squamous cell carcinoma or colorectal cancer at the START Center for Cancer Care in San Antonio, TX.
[Nektar Therapeutics]
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Fat1 Deletion Promotes Hybrid EMT State, Tumor Stemness and Metastasis

Using mouse models of skin squamous cell carcinoma and lung tumors, investigators found that deletion of Fat1 accelerated tumour initiation and malignant progression and promoted a hybrid epithelial-to-mesenchymal transition (EMT) phenotype.
[Nature]
Pastushenko, I., Mauri, F., Song, Y., de Cock, F., Meeusen, B., Swedlund, B., Impens, F., Van Haver, D., Opitz, M., Thery, M., Bareche, Y., Lapouge, G., Vermeersch, M., Van Eycke, Y.-R., Balsat, C., Decaestecker, C., Sokolow, Y., Hassid, S., Perez-Bustillo, A., … Blanpain, C. (2020). Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature, 1–8. https://doi.org/10.1038/s41586-020-03046-1 Cite
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