ALX Oncology to Collaborate with Merck on Phase II Immuno-Oncology Studies Evaluating ALX148, Targeting CD47, in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Head & Neck Cancer

ALX Oncology announced it has entered into a clinical trial collaboration with Merck to evaluate the combination of ALX148, an investigational next generation CD47 blocker, and KEYTRUDA®, Merck’s anti-PD-1 therapy, for the treatment of patients with Head & Neck Squamous Cell Carcinoma.
[ALX Oncology]
Press Release
Bookmark

No account yet? Register

0
Share

Prognostic Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
Full Article
Bookmark

No account yet? Register

0
Share

Altering MYC Phosphorylation in the Epidermis Increases the Stem Cell Population and Contributes to the Development, Progression, and Metastasis of Squamous Cell Carcinoma

To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scienttists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.
[Oncogenesis]
Wang, X., Langer, E. M., Daniel, C. J., Janghorban, M., Wu, V., Wang, X.-J., & Sears, R. C. (2020). Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma. Oncogenesis, 9(9), 1–13. https://doi.org/10.1038/s41389-020-00261-3 Cite
Full Article
Bookmark

No account yet? Register

0
Share

3D Co-Culture of Cancer-Associated Fibroblast with Oral Cancer Organoids

The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma.
[Journal of Dental Research]
Zhao, H., Jiang, E., & Shang, Z. (2020). 3D Co-culture of Cancer-Associated Fibroblast with Oral Cancer Organoids: Journal of Dental Research. https://doi.org/10.1177/0022034520956614 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Long Non-Coding RNA PICSAR Knockdown Inhibits the Progression of Cutaneous Squamous Cell Carcinoma by Regulating miR-125b/YAP1 Axis

The authors explored the precise role and mechanism of p38 inhibiting cutaneous squamous cell carcinoma associated lincRNA (PICSAR) in cutaneous squamous-cell carcinoma.
[Life Sciences]
Abstract
Bookmark

No account yet? Register

0
Share

The Potential Role of YAP in Head and Neck Squamous Cell Carcinoma

Researchers discuss the causes and functional consequences of YAP dysregulation in head and neck squamous cell carcinoma (HNSCC). They also address interactions between YAP and other oncogenic drivers of HNSCC.
[Experimental and Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

In Vitro and In Vivo Characterization of Cancer Stem‐Cell Subpopulations in Oral Squamous Cell Carcinoma

In vitro behavior of FACS‐sorted CD44HighESAHigh cancer stem cells (CSCs) and CD44HighESALow CSCs from oral squamous cell carcinoma cells was characterized by their ability to form colonies, migrate, proliferate, and to invade a solid matrix.
[Journal of Oral Pathology & Medicine]
Abstract
Bookmark

No account yet? Register

0
Share

Loss of Oral Mucosal Stem Cell Markers in Oral Submucous Fibrosis and Their Reactivation in Malignant Transformation

Investigators review the expression of oral mucosal stem cell markers in oral submucous fibrosis (OSF), oral potentially malignant disorders and oral squamous cell carcinoma to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF.
[International Journal of Oral Science]
Full Article
Bookmark

No account yet? Register

0
Share

Effects of Photobiomodulation on Cellular Viability and Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma

Researchers evaluated in vitro, the effects of photobiomodulation (PBM), with the same dosimetric parameters as those used in the clinic for oral mucositis prevention and treatment, on oral squamous cell carcinoma cellular viability, as well as PBM’s effect on cancer stem cell properties and its phenotype.
[Lasers in Medical Science]
Full Article
Bookmark

No account yet? Register

0
Share

Tumoral and Paratumoral NK Cells and CD8+ T Cells of Esophageal Carcinoma Patients Express High Levels of CD47

A total of 36 tissue samples from tumors, peritumoral tissue, and adjacent healthy esophageal tissue was obtained from 12 esophageal carcinoma patients, and the surface expression of CD47 was evaluated in NK cells, CD8+ T cells, and the nonlymphocyte cell fraction.
[Scientific Reports]
Strizova, Z., Vachtenheim, J., Snajdauf, M., Lischke, R., Bartunkova, J., & Smrz, D. (2020). Tumoral and paratumoral NK cells and CD8 + T cells of esophageal carcinoma patients express high levels of CD47. Scientific Reports, 10(1), 13936. https://doi.org/10.1038/s41598-020-70771-y Cite
Full Article
Bookmark

No account yet? Register

0
Share

Usefulness of 2D Shear Wave Elastography for the Diagnosis of Inguinal Lymph Node Metastasis of Malignant Melanoma and Squamous Cell Carcinoma

Scientists determined the presence or absence of metastatic lymphadenopathy in the inguinal lymph nodes of five patients with malignant melanoma and squamous cell carcinoma.
[Journal of Dermatology]
Full Article
Bookmark

No account yet? Register

0
Share
Share