C-FOS Drives Reversible Basal to Squamous Cell Carcinoma Transition

Researchers used surface markers of resistant basal cell carcinomas and patient single-cell and bulk transcriptomic data, and uncovered the dynamic roadmap of basal to squamous cell carcinoma transition.
[Cell Reports]
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DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression Via the MAPK/ERK/MMP2 Pathway

Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.
[Molecular Cancer Research]
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SEC61G Overexpression and DNA Amplification Correlates with Prognosis and Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma

SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated.
[Cancer Medicine]
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The Anti-Tumor Effect of Induced Pluripotent Stem Cells against Submandibular Gland Carcinoma in Rats Is Achieved via Modulation of the Apoptotic Response and the Expression of Sirt-1, TGF-β, and MALAT-1 in Cancer Cells

The authors investigated the contribution of the Bax, Sirt-1, TGF-β, and MALAT genes and/or their protein expression to the pathogenesis of submandibular carcinogenesis before and after iPSCs treatment.
[Molecular and Cellular Biochemistry]
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FLT3L Release by NK Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Investigators combined radiation, immunotherapies, genetic mouse models, and antibody depletion experiments to identify the role of NK cells in overcoming resistance to radiation therapy in orthotopic models of head and neck squamous cell carcinoma
[Clinical Cancer Research]
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Involvement of Felis catus Papillomavirus Type II in the Tumorigenesis of Feline Merkel Cell Carcinoma

Scientists hypothesized that Felis catus papillomavirus was involved in the development of merkel cell carcinoma in cats, similar to Squamous cell carcinoma and basal cell carcinoma.
[Veterinary Pathology]
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Chronic UV Radiation–Induced RORγt+ IL-22–Producing Lymphoid Cells Are Associated with Mutant KC Clonal Expansion

Scientists showed that mutant keratinocytes (KC) clone size was markedly reduced in the absence of RORγt+ lymphocytes or interleukin (IL)-22, both observed in association with expanding KC clones, and found that topical application of a RORγ/γt inhibitor during chronic ultraviolet (UV) exposure reduced local expression of IL-22 and IL-17A while markedly limiting mutant p53 KC clonal expansion.
[Proceedings of the National Academy of Sciences of the United States of America]
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TMED3 Promotes the Progression and Development of Lung Squamous Cell Carcinoma by Regulating EZR

The loss-of-function assays were used to investigate the effects of trafficking protein 3 on proliferation, apoptosis, cell cycle, and migration of lung squamous cell carcinoma cells.
[Cell Death & Disease]
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Non-Coding RNA Dysregulation in Skin Cancers

Researchers summarize the functional role of non-coding RNAs in skin cancers and their potential clinical application as biomarkers.
[Essays in Biochemistry]
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MMP1 Regulated by NEAT1/miR-361-5p Axis Facilitates the Proliferation and Migration of Cutaneous Squamous Cell Carcinoma via the Activation of Wnt Pathway

Scientists found that the expression of matrix metallopeptidase 1 (MMP1) was up-regulated in cutaneous squamous cell carcinoma (CSCC) cells, and knockdown of MMP1 suppressed cell proliferation and invasion in CSCC.
[Cancer Biology & Therapy]
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Mapping Lung Squamous Cell Carcinoma Pathogenesis Through In Vitro and In Vivo Models

Scientists discuss how molecular profiling of premalignant lesions and invasive lung squamous cell carcinoma (LUSC) has contributed to the refinement of in vitro and in vivo models, and in turn, how these systems have increased our understanding of LUSC biology and therapeutic vulnerabilities.
[Communications Biology]
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