squamous cell carcinoma

[Nature Communications] Investigators showed that super-enhancers played a critical role in the transcription of cancer stemness genes as well as pro-metastatic genes, thereby controlling their tumorigenic potential and metastasis.

[Oral Diseases] Researchers investigated whether lysine-specific demethylase 1 (LSD1) affected the development of oral squamous cell carcinoma (OSCC) by sustaining the CSCs from OSCC.

[BMC Pulmonary Medicine] Scientists comprehensively evaluated the expression of GPC3 in non-small cell lung cancer (NSCLC) and develop a risk-score model for predicting the prognosis of NSCLC.

[Oncogene] Investigators provided evidence that the CSC-related transcription factor Oct4 contributes to head and neck squamous cell carcinoma radioresistance by regulating DNA damage response and the CSC phenotype.

[Oncogenesis] The authors mapped the substrates of matrix metalloproteinase 8 (MMP8) to elucidate its previously shown tumor-protective role in oral tongue squamous cell carcinoma. MMP8 overexpressing (+) HSC-3 cells, previously demonstrated to have reduced migration and invasion, showed enhanced cell-cell adhesion.

[Cancers] The authors designed a dissection method for validating the use of a 15-gene hypoxia classifier, which was previously established for head and neck squamous cell carcinoma patients, to identify hypoxia in prostate cancer.