Gene Regulation Using Spherical Nucleic Acids to Treat Skin Disorders

The authors describe the production, structure and properties of spherical nucleic acids (SNAs); detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger receptors; and report how SNAs have been topically applied and intralesionally injected for skin disorders.
[Pharmaceuticals]
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Mesenchymal Stem Cells Functionalized Sonodynamic Treatment for Improving Therapeutic Efficacy and Compliance of Orthotopic Oral Cancer

Nanoengineered MSCs were developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy against oral squamous cell carcinoma along with good therapeutic compliance.
[Advanced Materials]
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Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion

Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]
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Stromal Microenvironment Promoted Infiltration in Esophageal Adenocarcinoma and Squamous Cell Carcinoma: A Multi-Cohort Gene-Based Analysis

Investigators proposed a practical classifier for the stromal microenvironment to predict the prognosis of esophageal carcinoma patients.
[Scientific Reports]
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Trichohyalin-Like 1 Protein Plays a Crucial Role in Proliferation and Anti-Apoptosis of Normal Human Keratinocytes and Squamous Cell Carcinoma Cells

Researchers examined the role of Trichohyalin-like 1 (TCHHL1) protein in normal human keratinocytes (NHKs) and squamous cell carcinoma. The knockdown of TCHHL1 by transfection with TCHHL1 siRNA significantly inhibited proliferation and induced the early apoptosis of NHKs.
[Cell Death Discovery]
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Integrative Transcriptomic Analysis for Linking Acute Stress Responses to Squamous Cell Carcinoma Development

In vitro, Oncostatin M promoted invasiveness of keratinocytes and cutaneous squamous cell carcinoma cells and suppressed apoptosis of irradiated keratinocytes.
[Scientific Reports]
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ALX Oncology to Collaborate with Merck on Phase II Immuno-Oncology Studies Evaluating ALX148, Targeting CD47, in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Head & Neck Cancer

ALX Oncology announced it has entered into a clinical trial collaboration with Merck to evaluate the combination of ALX148, an investigational next generation CD47 blocker, and KEYTRUDA®, Merck’s anti-PD-1 therapy, for the treatment of patients with Head & Neck Squamous Cell Carcinoma.
[ALX Oncology]
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Prognostic Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
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Altering MYC Phosphorylation in the Epidermis Increases the Stem Cell Population and Contributes to the Development, Progression, and Metastasis of Squamous Cell Carcinoma

To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scienttists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.
[Oncogenesis]
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3D Co-Culture of Cancer-Associated Fibroblast with Oral Cancer Organoids

The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma.
[Journal of Dental Research]
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Long Non-Coding RNA PICSAR Knockdown Inhibits the Progression of Cutaneous Squamous Cell Carcinoma by Regulating miR-125b/YAP1 Axis

The authors explored the precise role and mechanism of p38 inhibiting cutaneous squamous cell carcinoma associated lincRNA (PICSAR) in cutaneous squamous-cell carcinoma.
[Life Sciences]
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