The authors describe the production, structure and properties of spherical nucleic acids (SNAs); detail the mechanism of SNA uptake in keratinocytes, regulated by scavenger receptors; and report how SNAs have been topically applied and intralesionally injected for skin disorders.
[zotpress userid=’6807162′ items=’3LRRC2IS’ style=’apa’ cite=’yes’]
Nanoengineered MSCs were developed as a supersonosensitizer, named M/LPV/O2, for improving nondestructive sonodynamic therapy against oral squamous cell carcinoma along with good therapeutic compliance.
[zotpress userid=’6630899′ items=’A7VP4LPY’ style=’apa’ cite=’yes’]
Researchers hypothesized that head and neck squamous cell carcinoma recurrent tumors successfully evade anti-tumor immune response and aimed to reveal tumor immune microenvironment changes of primary tumors.
[Clinical Cancer Research]
[zotpress userid=’6445218′ items=’ZZF7XXX2′ style=’apa’ cite=’yes’]
Investigators proposed a practical classifier for the stromal microenvironment to predict the prognosis of esophageal carcinoma patients.
[zotpress userid=’6630899′ items=’WKCGUD3Z’ style=’apa’ cite=’yes’]
Researchers examined the role of Trichohyalin-like 1 (TCHHL1) protein in normal human keratinocytes (NHKs) and squamous cell carcinoma. The knockdown of TCHHL1 by transfection with TCHHL1 siRNA significantly inhibited proliferation and induced the early apoptosis of NHKs.
[Cell Death Discovery]
[zotpress userid=’6807162′ items=’VJ9YTQ6H’ style=’apa’ cite=’yes’]
In vitro, Oncostatin M promoted invasiveness of keratinocytes and cutaneous squamous cell carcinoma cells and suppressed apoptosis of irradiated keratinocytes.
[zotpress userid=’6807162′ items=’X8776UAE’ style=’apa’ cite=’yes’]
ALX Oncology announced it has entered into a clinical trial collaboration with Merck to evaluate the combination of ALX148, an investigational next generation CD47 blocker, and KEYTRUDA®, Merck’s anti-PD-1 therapy, for the treatment of patients with Head & Neck Squamous Cell Carcinoma.
Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
[zotpress userid=’1254621′ items=’NHLFHMGS’ style=’apa’ cite=’yes’]
To investigate whether and how altered MYC phosphorylation might affect squamous cell carcinoma development, progression, and metastasis, scienttists generated mice with inducible expression of MYCWT or MYCT58A in the basal layer of the skin epidermis.
[zotpress userid=’6807162′ items=’V5T7QXAI’ style=’apa’ cite=’yes’]
The three-dimensional organoid model was employed to investigate whether co-culture with paralleled cancer-associated fibroblasts promoted stem-like properties of oral squamous cell carcinoma.
[Journal of Dental Research]
[zotpress userid=’6807162′ items=’RMGTKCLC’ style=’apa’ cite=’yes’]
The authors explored the precise role and mechanism of p38 inhibiting cutaneous squamous cell carcinoma associated lincRNA (PICSAR) in cutaneous squamous-cell carcinoma.
[zotpress userid=’6807162′ items=’K2QZF4GE’ style=’apa’ cite=’yes’]