Researchers developed a mice model for studying the hematopoietic syndrome in the non-uniform or partial body exposure scenarios using the localized cobalt60 gamma radiation exposure.
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Functional studies with gene-overexpressed and gene-silenced DLBCL cell lines showed that expression of NANOG and HOXA9 promoted cell viability and inhibited apoptosis through suppression of G2 arrest in vitro and enhanced tumor formation and hepatosplenic infiltration in a tail-vein-injected mouse model.
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Researchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacts cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
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López-Sánchez, L. M., Mena, R., Guil-Luna, S., Mantrana, A., Peñarando, J., Toledano-Fonseca, M., Conde, F., De la Haba-Rodríguez, J. R., Aranda, E., & Rodríguez-Ariza, A. (2020). Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00507-z Cite
Scientists indicated that upregulation of miR-211 has tumor-suppressive properties by inhibiting TGF-β pathway activation via INHBA in prostate cancer stem cells.
[Cancer Gene Therapy]
OSTERIX, an OB‐specific zinc finger‐containing transcription factor was for the first time found to be expressed in gastrointestinal crypt cells, and SHP2 expression in the crypt Osx+ cells was critical for self‐renewal and proliferation.
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Researchers isolated epithelial cell adhesion molecule-positive biliary epithelial cells from the mouse intrahepatic bile duct, gallbladder, and extrahepatic bile duct and established organoids derived from these cells.
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Kasuga, A., Semba, T., Sato, R., Nobusue, H., Sugihara, E., Takaishi, H., Kanai, T., Saya, H., & Arima, Y. (n.d.). Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14703 Cite
The cytotoxic effect of diltiazem, gemcitabine, and 5-fluorouracil in single and combined forms against PANC-1 and AsPC-1 cells were assayed by MTT. Flow cytometric analysis was used for the determination of cell cycle, apoptosis, and stemness markers in pancreatic cancer cells.
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El-Mahdy, H. A., El-Husseiny, A. A., Kandil, Y. I., & Gamal El-Din, A. M. (2020). Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. Life Sciences, 118518. https://doi.org/10.1016/j.lfs.2020.118518 Cite
Scientists observed that patient-derived glioblastoma cells expressing shRNAs of VEGF or neuropilin-1 attenuated cancer stem cell markers, inhibited the tumor-initiating cell’s neurosphere-forming capacity, and migration.
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Angom, R. S., Mondal, S. K., Wang, F., Madamsetty, V. S., Wang, E., Dutta, S. K., Gulani, Y., Sarabia-Estrada, R., Sarkaria, J. N., Quiñones-Hinojosa, A., & Mukhopadhyay, D. (2020). Ablation of neuropilin-1 improves the therapeutic response in conventional drug-resistant glioblastoma multiforme. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01462-1 Cite
Investigators evaluated aspirin-mediated effects on phenotype and stem cell markers in intestinal organoids derived from mouse and human familial adenomatous polyposis patients. colorectal cancer cell lines were used to study effects on motility, invasion, Wnt signalling and epithelial-mesenchymal transition.
[Cellular and Molecular Gastroenterology and Hepatology]
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Dunbar, K., Valanciute, A., Lima, A., Vinuela, P. F., Jamieson, T., Rajasekaran, V., Blackmur, J., Ochocka-Fox, A.-M., Guazzelli, A., Cammareri, P., Arends, M. J., Sansom, O. J., Myant, K. B., Farrington, S. M., Dunlop, M. G., & Din, F. V. N. (2020). Aspirin rescues Wnt-driven stem-like phenotype in human intestinal organoids and increases the Wnt antagonist Dickkopf-1. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2020.09.010 Cite
Authors discuss the pathophysiological roles of special AT-rich binding protein-2 (SATB2) and assess whether it could be used as a therapeutic target for cancer.
[Journal of Cellular and Molecular Medicine]
Investigators showed that SPARC-related modular calcium-binding protein 2 transcript level was higher in colorectal cancer samples than in normal mucosa; this level was not associated with candidate cancer stem cell markers or intestinal stem cell markers except for OLFM4.
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