Silencing PTEN in the Fallopian Tube Promotes Enrichment of Cancer Stem Cell-Like Function through Loss of PAX2

Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
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Bacteria Induce Skin Regeneration via IL-1β Signaling

The Scientists assessed the function of skin bacteria in wound healing and wound-induced hair follicle neogenesis (WIHN), a rare adult organogenesis model.
[Cell Host & Microbe]
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Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
Barnett, A. M., Mullaney, J. A., Hendriks, C., Le Borgne, L., McNabb, W. C., & Roy, N. (2021). Porcine colonoids and enteroids keep the memory of their origin during regeneration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00420.2020 Cite
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CDK8 Maintains Stemness and Tumorigenicity of Glioma Stem Cells by Regulating the C-MYC Pathway

Investigators demonstrated how cyclin-dependent kinase 8 (CDK8) played an essential role in maintaining stemness and tumorigenicity in glioma stem cells.
[Oncogene]
Fukasawa, K., Kadota, T., Horie, T., Tokumura, K., Terada, R., Kitaguchi, Y., Park, G., Ochiai, S., Iwahashi, S., Okayama, Y., Hiraiwa, M., Yamada, T., Iezaki, T., Kaneda, K., Yamamoto, M., Kitao, T., Shirahase, H., Hazawa, M., Wong, R. W., … Hinoi, E. (2021). CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01745-1 Cite
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Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer

Combined bulk transcriptomic and single-cell RNA-sequencing analysis revealed decreased gene expression of markers for differentiated cells in patient-derived organoids derived from metastatic lesions.
[Stem Cell Reports]
Okamoto, T., duVerle, D., Yaginuma, K., Natsume, Y., Yamanaka, H., Kusama, D., Fukuda, M., Yamamoto, M., Perraudeau, F., Srivastava, U., Kashima, Y., Suzuki, A., Kuze, Y., Takahashi, Y., Ueno, M., Sakai, Y., Noda, T., Tsuda, K., Suzuki, Y., … Yao, R. (2021). Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.02.012 Cite
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Acquisition of Cancer Stem Cell Capacities after Spontaneous Cell Fusion

Cancer stem cells capacities were evaluated regarding capacity to form spheres, expression of stem cell markers and the presence of ALDHhigh cells.
[BMC Cancer]
Merle, C., Lagarde, P., Lartigue, L., & Chibon, F. (2021). Acquisition of cancer stem cell capacities after spontaneous cell fusion. BMC Cancer, 21(1), 241. https://doi.org/10.1186/s12885-021-07979-2 Cite
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Brg1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion

Investigators demonstrated the function of Brg1 in promoting hepatic progenitor cell expansion, liver cirrhosis, and ultimately intrahepatic cholangiocarcinoma development in chronically injured livers, which was largely dependent on Wnt/β‐catenin signaling.
[Hepatology]
Zhou, Y., Chen, Y., Zhang, X., Xu, Q., Wu, Z., Cao, X., Shao, M., Shu, Y., Lv, T., Lu, C., Xie, M., Wen, T., Yang, J., Shi, Y., & Bu, H. (n.d.). Brg1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31780 Cite
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Aortic Carboxypeptidase-Like Protein Regulates Vascular Adventitial Progenitor and Fibroblast Differentiation through Myocardin Related Transcription Factor A

Using purified mouse aortic adventitia Sca1+ progenitors, ACLP repressed stem cell markers and upregulated smooth muscle actin and collagen I expression.
[Scientific Reports]
Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A | Scientific Reports. (n.d.). Retrieved February 18, 2021, from https://www.nature.com/articles/s41598-021-82941-7 Cite
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Crenolanib Regulates ERk and AKT/mTOR Signaling Pathways in RAS/BRAF-Mutated Colorectal Cancer Cells and Organoids

Scientists used multiple colorectal cancer (CRC) cell lines to investigate the growth-inhibitory effect of crenolanib and its effect in combination with other cytotoxic agents. Primary cultures of patient-derived organoids, a model that reflects the heterogeneity of clinical CRC, were used to further validate the effects of crenolanib.
[Molecular Cancer Research]
Fujino, S., Miyoshi, N., Ito, A., Yasui, M., Ohue, M., Ogino, T., Takahashi, H., Uemura, M., Matsuda, C., Mizushima, T., Doki, Y., & Eguchi, H. (2021). Crenolanib regulates ERK and AKT/mTOR signaling pathways in RAS/BRAF-mutated colorectal cancer cells and organoids. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0600 Cite
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Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer

Researchers investigatef whether Cisplatin, Imatinib, and 5-Fluorouracil alter the tumoroid growth of metastatic colorectal cancer.
[Cells]
Sogawa, C., Eguchi, T., Namba, Y., Okusha, Y., Aoyama, E., Ohyama, K., & Okamoto, K. (2021). Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer. Cells, 10(2), 344. https://doi.org/10.3390/cells10020344 Cite
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Comparative Stemness and Differentiation of Luminal and Basal Breast Cancer Stem Cell Type under Glutamine-Deprivation

Scientists showed that breast cancer stem cells differentiated into CD24+ epithelial population under gln-deprivation and demonstrated increased expression of epithelial markers such as e-cadherin, claudin-1 and decreased expression of mesenchymal protein n-cadherin.
[Journal of Cell Communication and Signaling]
Jariyal, H., Gupta, C., Andhale, S., Gadge, S., & Srivastava, A. (2021). Comparative stemness and differentiation of luminal and basal breast cancer stem cell type under glutamine‐deprivation. Journal of Cell Communication and Signaling. https://doi.org/10.1007/s12079-020-00603-1 Cite
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