Targeting alpha2,3-Sialylated Glycan in Glioma Stem-Like Cells by Maackia amurensis Lectin-II: A Promising Strategy for Glioma Treatment

The authors established a new glioma stem-like cell, named U373-GSC, from the U373 glioma cell line. The cells exhibited stemness properties, e.g., expression of stem cell markers, self-renewal activity, multi-lineage differentiating abilities, and drug resistance.
[Experimental Cell Research]
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Phenotyping Clonal Populations of Glioma Stem Cell Reveals a High Degree of Plasticity in Response to Changes of Microenvironment

Investigators used a barcode labelling approach of glioma-initiating cells to generate clonal populations over a number of passages, in combination with phenotyping using the established stem cell markers CD133, CD15, CD44, and A2B5.
[Laboratory Investigation]
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Developmental Defects and Impaired Network Excitability in a Cerebral Organoid Model of KCNJ11 p.V59M-Related Neonatal Diabetes

Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.
[Scientific Reports]
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Single-Cell RNA Sequencing Reveals the Epithelial Cell Heterogeneity and Invasive Subpopulation in Human Bladder Cancer

Investigators applied droplet-based single-cell RNA sequencing (scRNA-seq) to acquire transcriptional profiles of 36 619 single cells isolated from seven patients.
[International Journal of Cancer]
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Gastric Cancer Stem Cells Survive in Stress Environments via Their Autophagy System

Scientists clarified the significance of autophagy systems of CSCs under stress environments. Four gastric cancer cell line were used.
[Scientific Reports]
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Loss of Numb Promotes Hepatic Progenitor Expansion and Intrahepatic Cholangiocarcinoma by Enhancing Notch Signaling

Numb silencing in cultured intrahepatic cholangiocarcinoma cells enhanced cell spheroid growth, invasion, metastasis, and the expression of stem cell markers.
[Cell Death & Disease]
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Fine-Tuned Repression of Drp1 Driven Mitochondrial Fission Primes a ‘Stem/Progenitor-Like State’ to Support Neoplastic Transformation

Using a newly derived carcinogen transformed human cell model, researchers demonstrated that fine-tuned Drp1 repression primed a slow cycling ‘stem/progenitor-like state’, which was characterized by small networks of fused mitochondria and a gene-expression profile with elevated functional stem/progenitor markers and their regulators.
[eLife]
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Cancerous and Non-Neoplastic Stem Cells in the Stomach Similarly Express CD44 and CD133

Scientists investigated the expression of CD44 and CD133 in gastric cancer and non-neoplastic gastric mucosa. They used samples of primary gastric adenocarcinomas, metastatic lymph nodes, intestinal metaplasia, and histologically normal gastric tissues of surgical margins.
[Acta Histochemica]
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lncRNA BORG:TRIM28 Complexes Drive Metastatic Progression by Inducing a6 Integrin/CD49f Expression in Breast Cancer Stem Cells

To elucidate the underlying mechanisms that drive breast cancer stem cells (BCSCs) tumorigenicity in TNBC, scientists identified the long noncoding RNA BMP/OP-Responsive Gene (BORG) as an enhancer of BCSC phenotypes.
[Molecular Cancer Research]
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Chronic Exposure to FGF2 Converts iPSCs into Cancer Stem Cells with an Enhanced Integrin/Focal Adhesion/PI3K/AKT Axis

Scientists designed a meta-analysis to assess gene expression profiles in different breast cancer cell lines focusing on the secretory factors responsible for conversion.
[Cancer Letters]
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Long Noncoding RNA LINC00261 Upregulates ITIH5 to Impair Tumorigenic Ability of Pancreatic Cancer Stem Cells

Researchers investigated the mechanism by which lncRNA LINC00261 affected the biological functions of cancer stem cells during the progression of pancreatic cancer.
[Cell Death Discovery]
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