stem cell markers

[Journal of Immunology] Scientists determined the immunomodulatory, antibacterial, and therapeutic potential of purified murine stem cell Ag-1+ lung MSCs using in vitro cell culture and an in vivo mouse model of pneumonia caused by K. pneumoniae.

[Journal of Cancer Research and Clinical Oncology] Musashi-1 was artificially downregulated in MCF-7 breast cancer cells and implications for cancer stem cell markers, cell apoptosis and apoptosis regulator p21, proliferation and radiation response were analyzed via flow cytometry and colony formation.

[Stem Cells and Development] Scientists reported that reduced death-associated protein kinase 1 (DAPK1) expression promoted stem cell-like characteristics of prostate cancer cells through activating zinc finger E-box binding homeobox-1 (ZEB1) via Hippo/YAP signaling pathway.

[Cell Death & Disease] Investigators identified PCGF1 as a crucial epigenetic regulator that sustained the stem cell-like phenotype of colorectal cancer (CRC). PCGF1 knockdown inhibited CRC stem cell proliferation and CRC stem cell enrichment.

[Cancer Discovery] The authors described a distinct subgroup of acute leukemia with expression of myeloid, T lymphoid and stem cell markers driven by aberrant allele-specific deregulation of BCL11B, a master transcription factor responsible for thymic T-lineage commitment and specification.

[Scientific Reports] Researchers investigated whether a generation of an adenovirus vectors that possess a suicide gene allow for detection of undifferentiated human iPSCs in preparations of human iPSC-derived neural progenitor cells, which have been expected to treat neurological disorders.