The HIF1α/HIF2α-miR210-3p Network Regulates Glioblastoma Cell Proliferation, Dedifferentiation and Chemoresistance through EGF under Hypoxic Conditions

In a hypoxic microenvironment the hypoxia-inducible factor 1α (HIF1α)/HIF2α-miR210-3p network promoted the malignant progression of glioblastoma through a positive feedback loop with epidermal growth factor (EGF).
[Cell Death & Disease]
The HIF1α/HIF2α-miR210-3p network regulates glioblastoma cell proliferation, dedifferentiation and chemoresistance through EGF under hypoxic conditions | Cell Death & Disease. (n.d.). Retrieved November 18, 2020, from https://www.nature.com/articles/s41419-020-03150-0 Cite
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Reduced EGFR and Increased miR-221 Is Associated with Increased Resistance to Temozolomide and Radiotherapy in Glioblastoma

Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment resistant Glioblastoma cell lines they observed that resistant cell lines lacked EGFR activation and expression.
[Scientific Reports]
Areeb, Z., Stuart, S. F., West, A. J., Gomez, J., Nguyen, H. P. T., Paradiso, L., Zulkifli, A., Jones, J., Kaye, A. H., Morokoff, A. P., & Luwor, R. B. (2020). Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma. Scientific Reports, 10(1), 17768. https://doi.org/10.1038/s41598-020-74746-x Cite
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Epigenetic Modulator Inhibition Overcomes Temozolomide Chemoresistance and Antagonizes Tumor Recurrence of Glioblastoma

Investigators identified a specific glioblastoma multiforme stem-like cells subset and showed that activity of these cells was positively regulated by stabilization of methyl CpG binding domain 3 protein.
[Journal of Clinical Investigation]
Moon, B.-S., Cai, M., Lee, G., Zhao, T., Song, X., Giannotta, S. L., Attenello, F. J., Yu, M., & Lu, W. (2020). Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI127916 Cite
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Patient-Derived Organoids and Orthotopic Xenografts of Primary and Recurrent Gliomas Represent Relevant Patient Avatars for Precision Oncology

Investigators report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient.
[Acta Neuropathologica]
Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., … Niclou, S. P. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02226-7 Cite
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Combination Therapy of Cold Atmospheric Plasma (CAP) With Temozolomide in the Treatment of U87MG Glioblastoma Cells

Investigators explored whether CAP, an ionized gas produced in laboratory settings and that operates at near room temperature, can enhance Temozolomide cytotoxicity on a glioblastoma cell line.
[Scientific Reports]
Raghuraman, S., Xie, J. Y., Giacobassi, M. J., Tun, J. O., Chase, K., Lu, D., Teichert, R. W., Porreca, F., & Olivera, B. M. (2020). Chronicling changes in the somatosensory neurons after peripheral nerve injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1922618117 Cite
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Wnt/β-Catenin Signaling Pathway Induces Autophagy-Mediated Temozolomide-Resistance in Human Glioblastoma

Investigators demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) was responsible for temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression.
[Cell Death & Disease]
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Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma With a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Scientists investigated a novel hypoxia inducible factor2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports]
Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor | Scientific Reports. (n.d.). Retrieved September 16, 2020, from https://www.nature.com/articles/s41598-020-72290-2 Cite
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EIF4A3-Induced Circular RNA ASAP1 (circASAP1) Promotes Tumorigenesis and Temozolomide Resistance of Glioblastoma via NRAS/MEK1/ERK1/2 Signaling

CircASAP1 expression was significantly up-regulated in recurrent glioblastoma (GBM) tissues and temozolomide-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and temozolomide-resistance, which could reduced by circASAP1 knockdown.
[Neuro-Oncology]
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Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

Researchers investigated the role of inflammasome sensor NACHT, LRR and PYD domains-containing protein (NLRP1) in acquired drug resistance to temozolomide in melanoma.
[Cancers]
Zhai, Z., Samson, J. M., Yamauchi, T., Vaddi, P. K., Matsumoto, Y., Dinarello, C. A., Ravindran Menon, D., & Fujita, M. (2020). Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma. Cancers, 12(9), 2518. https://doi.org/10.3390/cancers12092518 Cite
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A Highly Efficient Non-Viral Process for Programming Mesenchymal Stem Cells for Gene Directed Enzyme Prodrug Cancer Therapy

Scientists showed the high transfection efficiency of human adipose tissue derived-MSCs using a cost-effective and off-the-shelf Polyethylenimine, in the presence of histone deacetylase 6 inhibitor and fusogenic lipids.
[Scientific Reports]
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TGF-β1 Modulates Temozolomide Resistance in Glioblastoma via Altered microRNA Processing and Elevated MGMT

TGF-β1 treatment reduced cellular methylguanine DNA methyltransferase levels through suppressing the expression of miR-198. TGF-β1 upregulation did not affect KSRP expression in glioma cells.
[Neuro-Oncology]
Nie, E., Jin, X., Miao, F., Yu, T., Zhi, T., Shi, Z., Wang, Y., Zhang, J., Xie, M., & You, Y. (n.d.). TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT. Neuro-Oncology. https://doi.org/10.1093/neuonc/noaa198 Cite
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