Wnt/β-Catenin Signaling Pathway Induces Autophagy-Mediated Temozolomide-Resistance in Human Glioblastoma

Investigators demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) was responsible for temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) through ATG9B. DAB2IP sensitized GBM to TMZ and suppressed TMZ-induced autophagy by negatively regulating ATG9B expression.
[Cell Death & Disease]
Yun, E.-J., Kim, S., Hsieh, J.-T., & Baek, S. T. (2020). Wnt/β-catenin signaling pathway induces autophagy-mediated temozolomide-resistance in human glioblastoma. Cell Death & Disease, 11(9), 1–10. https://doi.org/10.1038/s41419-020-02988-8 Cite
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Attenuating Hypoxia Driven Malignant Behavior in Glioblastoma With a Novel Hypoxia-Inducible Factor 2 Alpha Inhibitor

Scientists investigated a novel hypoxia inducible factor2α inhibitor, PT2385, both in vitro, with low-passage patient-derived cell lines, and in vivo, using orthotopic models of glioblastoma.
[Scientific Reports]
Attenuating hypoxia driven malignant behavior in glioblastoma with a novel hypoxia-inducible factor 2 alpha inhibitor | Scientific Reports. (n.d.). Retrieved September 16, 2020, from https://www.nature.com/articles/s41598-020-72290-2 Cite
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EIF4A3-Induced Circular RNA ASAP1 (circASAP1) Promotes Tumorigenesis and Temozolomide Resistance of Glioblastoma via NRAS/MEK1/ERK1/2 Signaling

CircASAP1 expression was significantly up-regulated in recurrent glioblastoma (GBM) tissues and temozolomide-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and temozolomide-resistance, which could reduced by circASAP1 knockdown.
[Neuro-Oncology]
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Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

Researchers investigated the role of inflammasome sensor NACHT, LRR and PYD domains-containing protein (NLRP1) in acquired drug resistance to temozolomide in melanoma.
[Cancers]
Zhai, Z., Samson, J. M., Yamauchi, T., Vaddi, P. K., Matsumoto, Y., Dinarello, C. A., Ravindran Menon, D., & Fujita, M. (2020). Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma. Cancers, 12(9), 2518. https://doi.org/10.3390/cancers12092518 Cite
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A Highly Efficient Non-Viral Process for Programming Mesenchymal Stem Cells for Gene Directed Enzyme Prodrug Cancer Therapy

Scientists showed the high transfection efficiency of human adipose tissue derived-MSCs using a cost-effective and off-the-shelf Polyethylenimine, in the presence of histone deacetylase 6 inhibitor and fusogenic lipids.
[Scientific Reports]
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TGF-β1 Modulates Temozolomide Resistance in Glioblastoma via Altered microRNA Processing and Elevated MGMT

TGF-β1 treatment reduced cellular methylguanine DNA methyltransferase levels through suppressing the expression of miR-198. TGF-β1 upregulation did not affect KSRP expression in glioma cells.
[Neuro-Oncology]
Nie, E., Jin, X., Miao, F., Yu, T., Zhi, T., Shi, Z., Wang, Y., Zhang, J., Xie, M., & You, Y. (n.d.). TGF-β1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT. Neuro-Oncology. https://doi.org/10.1093/neuonc/noaa198 Cite
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Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment

The authors showed that heterogeneous glioblastoma cells express TNTs upon oxidative stress and temozolomide/ionizing radiation treatment.
[iScience]
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Flavagline Synthetic Derivative Induces Senescence in Glioblastoma Cancer Cells without Being Toxic to Healthy Astrocytes

Investigators explored the effect of FL3 in glioblastoma cells under normoxia and hypoxia conditions. They indicated that this synthetic flavagline inhibits cell proliferation and induced senescence in glioblastoma cells cultured under both conditions.
[Scientific Reports]
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EGFR/FOXO3a/BIM Signaling Pathway Determines Chemosensitivity of BMP4-Differentiated Glioma Stem Cells to Temozolomide

Scientists examined whether epidermal growth factor receptor (EGFR) signaling affects bone morphogenic protein 4-induced differentiation of glioma stem cells and their response to the alkylating drug temozolomide.
[Experimental and Molecular Medicine]
Ciechomska, I. A., Gielniewski, B., Wojtas, B., Kaminska, B., & Mieczkowski, J. (2020). EGFR/FOXO3a/BIM signaling pathway determines chemosensitivity of BMP4-differentiated glioma stem cells to temozolomide. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-0479-9 Cite
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ISL2 Modulates Angiogenesis through Transcriptional Regulation of ANGPT2 to Promote Cell Proliferation and Malignant Transformation in Oligodendroglioma

Investigators established novel oligodendroglioma patient tumor-derived orthotopic xenograft mouse models and cell lines to verify the role of ISL2 in regulating angiogenesis to promote oligodendroglioma growth and malignant transformation.
[Oncogene]
Qi, L., Wang, Z.-Y., Shao, X.-R., Li, M., Chen, S.-N., Liu, X.-Q., Yan, S., Zhang, B., Zhang, X.-D., Li, X., Zhao, W., Pan, J.-A., Zhao, B., & Zhang, X.-D. (2020). ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01411-y Cite
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