Viability Fingerprint of Glioblastoma Cell Lines: Roles of Mitotic, Proliferative, and Epigenetic Targets

Scientists compared the efficacy of focused modulation of a set of signaling pathways in two glioblastoma cell lines, U-251 MG and T98-G, using a panel of thirteen compounds targeting cell cycle progression, proliferation, epigenetic modifications, and DNA repair mechanism.
[Scientific Reports]
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Pyrvinium Pamoate Regulates MGMT Expression through Suppressing the Wnt/β-Catenin Signaling Pathway to Enhance the Glioblastoma Sensitivity to Temozolomide

Investigators found that pyrvinium pamoate (PP) and Temozolomide (TMZ) had synergistic effect on inhibiting the viability of glioblastoma multiforme (GBM) cells, and PP induced inhibition of MGMT and enhanced the TMZ chemosensitivity of GBM cells through down-regulating Wnt/β-catenin pathway.
[Cell Death Discovery]
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Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model

Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.
[Molecular Cancer Research]
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AEG-1 Silencing Attenuates M2-Polarization of Glioma-Associated Microglia/Macrophages and Sensitizes Glioma Cells to Temozolomide

Researchers showed here that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.
[Scientific Reports]
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Elucidating the Mechanisms of Temozolomide Resistance in Gliomas and the Strategies to Overcome the Resistance

Scientists summarize different strategies that intensify the temozolomide effect such as MGMT inhibition, development of novel imidazotetrazine analog, and combination therapy; with an aim to incorporate a successful treatment and increased overall survival in glioblastoma patients.
[Biochimica et Biophysica Acta-Reviews On Cancer]
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Benzimidazoles Induce Concurrent Apoptosis and Pyroptosis of Human Glioblastoma Cells via Arresting Cell Cycle

By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.
[Acta Pharmacologica Sinica]
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Molecular Characterization of AEBP1 at Transcriptional Level in Glioma

Three datasets were used to perform the analysis to search for the key genes related to glioma stem cell, temozolomide resistance, and prognosis. The key gene for further research was selected by reviewing the previous studies.
[Biomed Research International]
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Identification of Pimavanserin Tartrate as a Potent Ca2+-Calcineurin-NFAT Pathway Inhibitor for Glioblastoma Therapy

Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for Glioblastoma multiforme therapy.
[Acta Pharmacologica Sinica]
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Autophagy Inhibition Reinforces Stemness Together with Exit from Dormancy of Polydisperse Glioblastoma Stem Cells

The authors silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.
[Aging-Us]
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Inhibition of Metabotropic Glutamate Receptor III Facilitates Sensitization to Alkylating Chemotherapeutics in Glioblastoma

Researchers mapped the manifold effects of glutamate signaling in glioblastoma (GBM) as the basis to further discover the regulatory role and interactions of specific receptors, within the GBM microenvironment.
[Cell Death & Disease]
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CD90low Glioma-Associated Mesenchymal Stromal/Stem Cells Promote Temozolomide Resistance by Activating FOXS1-Mediated Epithelial-Mesenchymal Transition in Glioma Cells

Scientists explored the effect and mechanism of glioma-associated MSCs on resistance to temozolomide in glioma cells.
[Stem Cell Research & Therapy]
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