temozolomide

[Acta Pharmacologica Sinica] Researchers carried out research to discover a novel alternative drug targeting the oncogenic NFAT signaling pathway for Glioblastoma multiforme therapy.

[Aging-Us] The authors silenced two autophagy related genes -either Beclin1 or ATG5- by shRNA and they explored the ensuing consequences on CSCs markers’ expression and functionalities.

[Cell Death & Disease] Researchers mapped the manifold effects of glutamate signaling in glioblastoma (GBM) as the basis to further discover the regulatory role and interactions of specific receptors, within the GBM microenvironment.

[Stem Cell Research & Therapy] Scientists explored the effect and mechanism of glioma-associated MSCs on resistance to temozolomide in glioma cells.

[ACS Applied Materials & Interfaces] Researchers established a niche for glioblastoma stem-like cell selection as a platform and facilitate the assessment of differentiation therapy on glioblastoma multiforme cancer stem-like colonies by retinoic acid with temozolomide-loaded gold nanoparticles associated with low-intensity ultrasound.

[Scientific Reports] Researchers hypothesized that activating transcription factor 4 was essential for the adaptation of human glioblastoma cells to the conditions of the tumor microenvironment and contributed to therapy resistance against chemotherapy.