temozolomide

[Cell Research] Researchers uncovered that pericytes potentiated DNA damage repair in glioblastoma cells residing in the perivascular niche, which induced temozolomide chemoresistance.

[Molecular Therapy-Nucleic Acids] Scientists screened multi-layer molecular data of 36 pancreatic cancer cell lines, including gene mutation, gene expression, miRNA expression, and protein profiles.

[IN8bio, Inc.] IN8bio, Inc. announced an update from the ongoing Phase I clinical trial of INB-200, its DeltEx drug resistant immunotherapy , MGMT-gene modified gamma delta T-cells in patients with newly diagnosed GBM.

[Radiotherapy and Oncology] Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improves the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.

[Cancer Gene Therapy] Investigators found that elevation of GIGYF2 expression impaired cell migration and enhanced temozolomide sensitivity of human glioma cells.

[PLoS One] To improve treatment of glioblastoma, including those resistant to temozolomide , we explored the potential of targeting dopamine receptor signaling.