TGFβ

[Molecular Oncology] The glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.

[General and Comparative Endocrinology] Using MSCs from p62 knockout adult mice, the authors investigated the effect of p62 on MSC survival and bone-forming molecule cascades.

[Science Advances] Loss- and gain-of-function approaches demonstrated that plant homeodomain finger protein 8 (PHF8) promoted cell invasion without affecting proliferation in vitro and increased dissemination.

[Scientific Reports] To identify novel drug targets and uncover potential mechanisms by which these drugs attenuate fibrosis, scientists performed an integrative ‘omics analysis of transcriptomic and proteomic responses to TGFβ1-stimulated lung fibroblasts.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Kinase inhibitor of IRE1α treatment increased the differentiation of Krt19CreERT2-lineage-traced damage-associated transient progenitors (DATPs) into type 1 alveolar epithelial cells after bleomycin injury, indicating that relief from IRE1α signaling enabled DATPs to exit the transitional state.

[Cell Death & Disease] Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.