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TGFβ

Isoform Specific Anti-TGFβ Therapy Enhances Antitumor Efficacy in Mouse Models of Cancer

[Communications Biology] Using B16 mouse melanoma and CT26 colon carcinoma as models of stroma-poor tumors, researchers demonstrated that myeloid/dendritic cells were the main sources of TGFβ1 and TGFβ3.

TGFβ Signaling Modifies Hematopoietic Acute Inflammatory Response to Drive Bone Marrow Failure

[Haematologica] Scientists examined the effect of increased TGFβ signaling in combination or not with an acute innate immune challenge using polyinosinc:polycytidilic acid on the hematopoietic system without genetic mutations.

Regulatory T Cells Promote Cancer Immune-Escape through Integrin αvβ8-Mediated TGF-β Activation

[Nature Communications] The authors showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin are the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor micro-environment.

Regulatory T Cells Promote Cancer Immune-Escape through Integrin αvβ8-Mediated TGF-β Activation

[Nature Communications] Scientists showed in mouse melanoma and breast cancer models that regulatory T cells expressing the β8 chain of αvβ8 integrin were the main cell type in the tumors that activated TGFβ, produced by the cancer cells and stored in the tumor microenvironment.

Increased Abundance of Cbl E3 Ligases Alters PDGFR Signaling in Recessive Dystrophic Epidermolysis Bullosa

[Matrix Biology] Investigators indicated that elevated TGFβ signaling led to an attenuated response to growth factors, which contributed to impaired dermal wound healing in recessive dystrophic epidermolysis bullosa.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

[Nature Communications] Researchers showed that human hepatic organoids, engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD), developed the key features of ARPKD liver pathology in only 21 days.

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