TGFβ

[eLife] The authors demonstrate that TGFβ signaling was required to maintain naïve human PSCs (hPSCs). The downstream effector proteins – SMAD2/3 – bound common sites in naïve and primed hPSCs, including shared pluripotency genes.

[Biomaterials] In vitro chemical induction with RepSox generated chemically induced mammary epithelial cells (CiMECs) with milk secreting functions from goat ear fibroblasts (GEFs). Single-cell RNA sequencing revealed that during the reprogramming process, GEFs may have sequentially undergone embryonic ectoderm-like and different MEC developmental states.

[Journal of Clinical Investigation] Scientists found that CD4+ Tfh TIL, CD8+ TIL and TIL-B, co-localizing in TLS, all expressed the CXCL13 receptor CXCR5.

[Nature Immunology] Investigators analyzed tissue-resident memory T cell (TRM) heterogeneity between organs and found that the different environments in which these cells differentiate dictated TRM cell function, durability and malleability.

[Cell Death & Differentiation] Investigators identified tetraspanin CD63 as a novel functional marker of HSCs in mice and showed that CD63 was unevenly expressed on the cell surface in HSC populations.

[Scientific Reports] Scientists provided the transcriptional landscape of TNBC in response to TGFβ activation and subsequent inhibition employing SB431542, selective TGFβ1 Receptor ALK5 Inhibitor.