Tag Archives: TNF-α

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Erk Signaling Mediates Resistance to Immunomodulatory Drugs in the Bone Marrow Microenvironment

Investigators identified that tumor necrosis factor receptor-associated factor 2 knockdown/knockout in multiple myeloma cells mediated immunomodulatory drug resistance via activation of noncanonical nuclear factor κB and extracellular signal–regulated kinase (ERK) signaling.

[Science Advances]

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Inhibition of Aberrant Tissue Remodeling by Mesenchymal Stromal Cells Singly Coated with Soft Gels Presenting Defined Chemomechanical Cues

The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.

[Nature Biomedical Engineering]

Abstract Press Release

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Epithelial PBLD Attenuates Intestinal Inflammatory Response and Improves Intestinal Barrier Function by Inhibiting NF-κB Signaling

Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.

[Cell Death & Disease]

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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Experimental Autoimmune Encephalomyelitis via Regulating Pro and Anti-Inflammatory Cytokines

Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.

[Scientific Reports]

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Integrated Metabolomic Analysis and Cytokine Profiling Define Clusters of Immuno-Metabolic Correlation in New-Onset Psoriasis

Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.

[Scientific Reports]

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Circular RNA circACSL1 Aggravated Myocardial Inflammation and Myocardial Injury by Sponging miR-8055 and Regulating MAPK14 Expression

Researchers determined a novel circRNA, circACSL1, which was significantly upregulated in the acute phase of myocarditis, by using lipopolysaccharide to induce inflammatory responses in the human cardiomyocytes line.

[Cell Death & Disease]

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STAT3/SH3PXD2A-AS1/miR-125b/STAT3 Positive Feedback Loop Affects Psoriasis Pathogenesis via Regulating Human Keratinocyte Proliferation

SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.

[Cytokine]

Abstract

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Metformin Ameliorates Scleroderma via Inhibiting Th17 Cells and Reducing mTOR-STAT3 Signaling in Skin Fibroblasts

Scientists measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.

[Journal of Translational Medicine]

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Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

Scientists investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.

[Biomolecules]

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A Novel Strategy for Isolation of Mice Bone Marrow Endothelial Cells (BMECs)

Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.

[Stem Cell Research & Therapy]