Hepatic Stem Cell Numb Gene Is a Potential Target of Huang Qi Decoction Against Cholestatic Liver Fibrosis

Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived mesenchymal stem cells with knocked down Numb gene were treated with Huang Qi Decoction.
[Scientific Reports]
Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis | Scientific Reports. (n.d.). Retrieved October 19, 2020, from https://www.nature.com/articles/s41598-020-74324-1 Cite
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New Treatment Addressing the Pathogenesis of Psoriasis

Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
[International Journal of Molecular Sciences]
Tokuyama, M., & Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. International Journal of Molecular Sciences, 21(20), 7488. https://doi.org/10.3390/ijms21207488 Cite
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Hepatic Stem Cell Numb Gene Is a Potential Target of Huang Qi Decoction against Cholestatic Liver Fibrosis

Cholestatic liver fibrosis rats transplanted into rat bone marrow-derived MSCs with knocked down Numb gene were treated with Huang Qi Decoction (HQD). Simultaneously, Numb gene knockdown was also performed in the WB-F344 cell line and then treated with refined HQD .
[Scientific Reports]
Xu, W., Xu, Y., Zhang, X., Xu, Y., Jian, X., Chen, J., Chen, G., Zhang, H., Liu, P., & Mu, Y. (2020). Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis. Scientific Reports, 10(1), 17486. https://doi.org/10.1038/s41598-020-74324-1 Cite
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Engineered Cardiac Tissues: A Novel In Vitro Model to Investigate the Pathophysiology of Mouse Diabetic Cardiomyopathy

Researchers developed a murine-based engineered cardiac tissues (ECTs) model to investigate cardiac injury produced by advanced glycation end-products (AGEs). One findinf was that AGEs treatment significantly increased the markers of fibrosis (TGF-β, α-SMA, Ctgf, Collagen I-α1, Collagen III-α1, and Fn1) and hypertrophy.
[Acta Pharmacologica Sinica]
Wang, X., Chen, X., Yu, H., Tan, Y., Lin, Q., Keller, B. B., Zheng, Y., & Cai, L. (2020). Engineered cardiac tissues: a novel in vitro model to investigate the pathophysiology of mouse diabetic cardiomyopathy. Acta Pharmacologica Sinica, 1–10. https://doi.org/10.1038/s41401-020-00538-8 Cite
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Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection in Vitro

The authors suggest differential ability of specific Human Milk Oligosaccharides(HMOs) in modulating the intestinal barrier and support the potential of supplementation with combinations of available HMOs to promote gut health and protect against intestinal inflammatory disorders.
[Nutrients]
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Therapeutic Angiogenesis Using Autologous Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischaemia in Japan: A Clinical Pilot Study

Adipose tissue was obtained by ordinary liposuction method. Isolated ADRCs were injected into the ischaemic limb. Scientists performed TACT-ADRC procedure in five patients with CLI.
[Scientific Reports]
Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study | Scientific Reports. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41598-020-73096-y Cite
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EZH2-Dependent Epigenetic Modulation of Histone H3 Lysine-27 Contributes to Psoriasis by Promoting Keratinocyte Proliferation

The authors found that EZH2 and H3K27me3 were both overexpressed in the epidermis of psoriatic lesional skin compared to normal skin. In vitro, the expression of EZH2 and H3K27me3 was stimulated in human keratinocytes treated with mixture of psoriasis-related cytokines pool.
[Cell Death & Disease]
EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation | Cell Death & Disease. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41419-020-03028-1 Cite
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HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk

HUVECs or human coronary artery endothelial cells were pre-treated with the antiretrovirals abacavir sulphate, tenofovir disoproxil fumarate or tenofovir alafenamide.
[Circulation Research]
Khawaja Akif A, Taylor Kirk A, Lovell Andrew O, Nelson Mark, Gazzard Brian, Boffito Marta, & Emerson Michael. (n.d.). HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316477 Cite
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Repurposing a Novel Anti-Cancer RXR Agonist to Attenuate Acute GVHD and Maintain Graft-Versus-Leukemia Responses

The authors showed that in vivo IRX4204 was compared favorably with FK506 in abrogating acute graft-versus-host disease, which was associated with inhibiting allogeneic donor T cell proliferation, reducing T helper 1 differentiation and promoting regulatory T cell generation.
[Blood]
Thangavelu, G., Wang, C., Loschi, M., Saha, A., Osborn, M., Furlan, S. N., Aoyama, K., McDonald-Hyman, C., Aguilar, E. G., Janesick, A. S., Chandraratna, R. A., Refaeli, Y., Panoskaltsis-Mortari, A., MacDonald, K. P., Hill, G. R., Zeiser, R., Maillard, I., Serody, J., Murphy, W. J., … Blazar, B. R. (n.d.). Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses. Blood. https://doi.org/10.1182/blood.2020005628 Cite
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Exploring the Action of RGDV-Gemcitabine on Tumor Metastasis, Tumor Growth and Possible Action Pathway

Thereby Arg-Gly-Asp-Val-gemcitabine was able to inhibit the invasion, migration and adhesion of serum-starved A549 cells in vitro.
[Scientific Reports]
Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway | Scientific Reports. (n.d.). Retrieved September 25, 2020, from https://www.nature.com/articles/s41598-020-72824-8 Cite
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Peptidome Analysis of Umbilical Cord Mesenchymal Stem Cell (hUC-MSC) Conditioned Medium from Preterm and Term Infants

Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
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