HGK Promotes Metastatic Dissemination in Prostate Cancer

Investigators showed that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibited metastatic prostate cancer cells migration and clonogenic properties.
[Scientific Reports]
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Erk Signaling Mediates Resistance to Immunomodulatory Drugs in the Bone Marrow Microenvironment

Investigators identified that tumor necrosis factor receptor-associated factor 2 knockdown/knockout in multiple myeloma cells mediated immunomodulatory drug resistance via activation of noncanonical nuclear factor κB and extracellular signal–regulated kinase (ERK) signaling.
[Science Advances]
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Inhibition of Aberrant Tissue Remodeling by Mesenchymal Stromal Cells Singly Coated with Soft Gels Presenting Defined Chemomechanical Cues

The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.
[Nature Biomedical Engineering]
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Epithelial PBLD Attenuates Intestinal Inflammatory Response and Improves Intestinal Barrier Function by Inhibiting NF-κB Signaling

Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.
[Cell Death & Disease]
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Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Experimental Autoimmune Encephalomyelitis via Regulating Pro and Anti-Inflammatory Cytokines

Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.
[Scientific Reports]
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Integrated Metabolomic Analysis and Cytokine Profiling Define Clusters of Immuno-Metabolic Correlation in New-Onset Psoriasis

Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.
[Scientific Reports]
Tarentini, E., Odorici, G., Righi, V., Paganelli, A., Giacomelli, L., Mirisola, V., Mucci, A., Benassi, L., D’Aversa, E., Lasagni, C., Kaleci, S., Reali, E., & Magnoni, C. (2021). Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis. Scientific Reports, 11(1), 10472. https://doi.org/10.1038/s41598-021-89925-7 Cite
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Circular RNA circACSL1 Aggravated Myocardial Inflammation and Myocardial Injury by Sponging miR-8055 and Regulating MAPK14 Expression

Researchers determined a novel circRNA, circACSL1, which was significantly upregulated in the acute phase of myocarditis, by using lipopolysaccharide to induce inflammatory responses in the human cardiomyocytes line.
[Cell Death & Disease]
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STAT3/SH3PXD2A-AS1/miR-125b/STAT3 Positive Feedback Loop Affects Psoriasis Pathogenesis via Regulating Human Keratinocyte Proliferation

SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.
[Cytokine]
STAT3/SH3PXD2A-AS1/miR-125b/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation. (2021). Cytokine, 155535. https://doi.org/10.1016/j.cyto.2021.155535 Cite
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Metformin Ameliorates Scleroderma via Inhibiting Th17 Cells and Reducing mTOR-STAT3 Signaling in Skin Fibroblasts

Scientists measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.
[Journal of Translational Medicine]
Moon, J., Lee, S., Choi, J. W., Lee, A. R., Yoo, J. H., Moon, S.-J., Park, S.-H., & Cho, M.-L. (2021). Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. Journal of Translational Medicine, 19(1), 192. https://doi.org/10.1186/s12967-021-02860-z Cite
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Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

Scientists investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.
[Biomolecules]
James, S., Aparna, J. S., Babu, A., Paul, A. M., Lankadasari, M. B., Athira, S. R., Kumar, S. S., Vijayan, Y., Namitha, N. N., Mohammed, S., Reshmi, G., & Harikumar, K. B. (2021). Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer. Biomolecules, 11(5), 661. https://doi.org/10.3390/biom11050661 Cite
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A Novel Strategy for Isolation of Mice Bone Marrow Endothelial Cells (BMECs)

Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Smith, A. O., Adzraku, S. Y., Ju, W., Qiao, J., Xu, K., & Zeng, L. (2021). A novel strategy for isolation of mice bone marrow endothelial cells (BMECs). Stem Cell Research & Therapy, 12(1), 267. https://doi.org/10.1186/s13287-021-02352-3 Cite
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