Tag Archives: TNF-α

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Genetic Deletion of the Cannabinoid Receptors CB1 and CB2 Enhances Inflammation with Diverging Effects on Skin Wound Healing in Mice

In order to clarify the role of endocannabinoid system receptors in wound healing, excisional wounds were created on wildtype and CB1 and CB2 knockout mice.

[Life Sciences]

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TSSK4 Upregulation in Alveolar Epithelial Type-II Cells Facilitates Pulmonary Fibrosis through HSP90-AKT Signaling Restriction and AT-II Apoptosis

Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis, but the regulatory mechanism remains unclear. Scientists reported that alveolar epithelial type-II cells played important roles in pathological process of pulmonary fibrosis.

[Cell Death & Disease]

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A Modified Animal Model of Hepatic Regeneration Induced by Hilar Bile Duct Ligation

Scientists aimed to establish a new type of rapid liver hyperplasia model induced mainly by bile acid pathway through hepatoenteral circulation with hilar bile duct ligation. Immunohistochemistry results confirmed the proliferation of hepatocytes in the unligated liver lobe.

[Scientific Reports]

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Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.

[Stem Cells and Development]

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Rutin Inhibited the Advanced Glycation End Products-Stimulated Inflammatory Response and Extracellular Matrix Degeneration via Targeting TRAF-6 and BCL-2 Proteins in Mouse Model of Osteoarthritis

Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.

[Aging]

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TNF-α Synergises with IFN-γ to Induce Caspase-8-JAK1/2-STAT1-Dependent Death of Intestinal Epithelial Cells

Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.

[Cell Death & Disease]

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Doxorubicin Suppresses Chondrocyte Differentiation by Stimulating ROS Production

Scientists explored the specific mechanism of doxorubicin in osteoarthritis (OA). A mouse OA model was established by destabilizing the medial meniscus, and the role of DOX was determined by intraperitoneally injecting five or ten mg/kg DOX.

[European Journal of Pharmaceutical Sciences]

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Conditioned Medium from Stem Cells Derived from Human Exfoliated Deciduous Teeth Ameliorates NASH via the Gut-Liver Axis

The authors examined the benefits of serum-free conditioned medium from stem cells derived from human exfoliated deciduous teeth on a murine non-alcoholic steatohepatitis (NASH) model induced by a combination of Western diet and repeated administration of low doses of carbon tetrachloride intraperitoneally, focusing on the gut-liver axis.

[Scientific Reports]

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Cytosolic-DNA-Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

Stimulator of IFN genes (STING) is a universal receptor that recognizes cytosolic DNA and triggers innate immune activation. Investigators elucidated the role of STING in the inflammation during psoriasis.

[Journal of Investigative Dermatology]

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Histone Deacetylase HDAC4 Participates in the Pathological Process of Myocardial Ischemia-Reperfusion Injury via MEKK1/JNK Pathway by Binding to miR-206

Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.

[Cell Death Discovery]

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