Investigators showed that genetic deletion of MAP4K4 or pharmacological inhibition of its encoded kinase, HGK, inhibited metastatic prostate cancer cells migration and clonogenic properties.
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Investigators identified that tumor necrosis factor receptor-associated factor 2 knockdown/knockout in multiple myeloma cells mediated immunomodulatory drug resistance via activation of noncanonical nuclear factor κB and extracellular signal–regulated kinase (ERK) signaling.
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The authors showed that MSCs singly coated with a soft conformal gel presenting defined chemomechanical cues promoted matrix remodeling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha.
[Nature Biomedical Engineering]
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Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.
[Cell Death & Disease]
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Scientists investigated the effect of extracellular vesicles derived from human umbilical cord-MSC on the clinical score and inflammatory/anti-inflammatory cytokines on the EAE mouse model.
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Researchers analyzed the metabolic and cytokine/chemokine profiles in serum and skin from patients with new-onset psoriasis and healthy subjects by HR-MAS NMR and Bio-Plex immunoassay.
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Tarentini, E., Odorici, G., Righi, V., Paganelli, A., Giacomelli, L., Mirisola, V., Mucci, A., Benassi, L., D’Aversa, E., Lasagni, C., Kaleci, S., Reali, E., & Magnoni, C. (2021). Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis. Scientific Reports, 11(1), 10472. https://doi.org/10.1038/s41598-021-89925-7 Cite
Researchers determined a novel circRNA, circACSL1, which was significantly upregulated in the acute phase of myocarditis, by using lipopolysaccharide to induce inflammatory responses in the human cardiomyocytes line.
[Cell Death & Disease]
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SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.
Scientists measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.
[Journal of Translational Medicine]
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Moon, J., Lee, S., Choi, J. W., Lee, A. R., Yoo, J. H., Moon, S.-J., Park, S.-H., & Cho, M.-L. (2021). Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts. Journal of Translational Medicine, 19(1), 192. https://doi.org/10.1186/s12967-021-02860-z Cite
Scientists investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems. In RAW 264.7 cells, treatment with cardamonin showed a reduced nitrous oxide production without affecting the cell viability and decreased the expression of iNOS, TNF-α, and IL-6, and inhibited NF-kB signaling which emphasizes the role of cardamonin as an anti-inflammatory molecule.
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James, S., Aparna, J. S., Babu, A., Paul, A. M., Lankadasari, M. B., Athira, S. R., Kumar, S. S., Vijayan, Y., Namitha, N. N., Mohammed, S., Reshmi, G., & Harikumar, K. B. (2021). Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer. Biomolecules, 11(5), 661. https://doi.org/10.3390/biom11050661 Cite
Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]