Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α

Researchers investigated the roles of p53, p16INK4a, and p19ARF in the regulation of self-renewal and proliferation of mammary epithelial cells.
[Stem Cell Reports]
Pai Bellare, G., Saha, B., & Patro, B. S. (2021). Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition. British Journal of Cancer, 1–15. https://doi.org/10.1038/s41416-020-01238-0 Cite
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Weighted Gene Coexpression Network and Experimental Analyses Identify lncRNA SPRR2C as a Regulator of the IL-22-Stimulated HaCaT Cell Phenotype through the miR-330/STAT1/S100A7 Axis

Scientists identified lncRNA SPRR2C (small proline-rich protein 2C) as a hub gene with a critical effect on the pathogenesis of psoriasis and response to treatment using both weighted gene coexpression network analysis and differential expression analysis. SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment.
[Cell Death & Disease]
Luo, M., Huang, P., Pan, Y., Zhu, Z., Zhou, R., Yang, Z., & Wang, C. (2021). Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-020-03305-z Cite
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Dermal Fibroblasts Cultured from Donors with Type 2 Diabetes Mellitus Retain an Epigenetic Memory Associated with Poor Wound Healing Responses

Dermal fibroblasts (DF) are critical for effective wound healing, so the authors sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
[Scientific Reports]
Al-Rikabi, A. H. A., Tobin, D. J., Riches-Suman, K., & Thornton, M. J. (2021). Dermal fibroblasts cultured from donors with type 2 diabetes mellitus retain an epigenetic memory associated with poor wound healing responses. Scientific Reports, 11(1), 1474. https://doi.org/10.1038/s41598-020-80072-z Cite
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Fenofibrate Attenuates Doxorubicin-Induced Cardiac Dysfunction in Mice via Activating the eNOS/EPC Pathway

Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model.
[Scientific Reports]
Huang, W.-P., Yin, W.-H., Chen, J.-S., Huang, P.-H., Chen, J.-W., & Lin, S.-J. (2021). Fenofibrate attenuates doxorubicin-induced cardiac dysfunction in mice via activating the eNOS/EPC pathway. Scientific Reports, 11(1), 1159. https://doi.org/10.1038/s41598-021-80984-4 Cite
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Development of Hematopoietic Syndrome Mice Model for Localized Radiation Exposure

Researchers developed a mice model for studying the hematopoietic syndrome in the non-uniform or partial body exposure scenarios using the localized cobalt60 gamma radiation exposure.
[Scientific Reports]
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Reprogramming Immunosuppressive Myeloid Cells by Activated T Cells Promotes the Response to Anti-PD-1 Therapy in Colorectal Cancer

The levels of infiltrating myeloid-derived suppressor cells (MDSCs) were significantly higher in the non-responding organoids and were selectively reduced in the responding group, with MDSCs showing increased apoptosis and attenuated functional activity after anti-PD-1 treatment.
[Signal Transduction and Targeted Therapy]
Chen, J., Sun, H.-W., Yang, Y.-Y., Chen, H.-T., Yu, X.-J., Wu, W.-C., Xu, Y.-T., Jin, L.-L., Wu, X.-J., Xu, J., & Zheng, L. (2021). Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer. Signal Transduction and Targeted Therapy, 6(1), 1–14. https://doi.org/10.1038/s41392-020-00377-3 Cite
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Topical Application of Peptide-Chondroitin Sulfate Nanoparticles Allows Efficient Photoprotection in Skin

The authors describe a method of delivery of chondroitin sulfate to skin as nanoparticles and demonstrated its anti-inflammatory and antioxidant role using UV irradiation as a model condition.
[ACS Applied Materials & interfaces]
Mishra, S., G, B. R., Pal, S., Bano, S., Gupta, A., Kumari, A., & Ganguli, M. (2021). Topical Application of Peptide–Chondroitin Sulfate Nanoparticles Allows Efficient Photoprotection in Skin. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.0c22011 Cite
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Hepatotoxicity Prevention in Acetaminophen-Induced HepG2 Cells by Red Betel (Piper crocatum Ruiz and Pav) Extract from Indonesia via Antioxidant, Anti-Inflammatory, and Anti-Necrotic

Red betel leaves extract (RBLE) protective effect against APAP-induced HepG2 cells was determined. APAP-induced HepG2 as hepatotoxicity cell model was treated with RBLE at 25 and 100 μg/mL.
[Heliyon]
Ginting, C. N., Lister, I. N. E., Girsang, E., Widowati, W., Yusepany, D. T., Azizah, A. M., & Kusuma, H. S. W. (2021). Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic. Heliyon, 7(1). https://doi.org/10.1016/j.heliyon.2020.e05620 Cite
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Effects and Safety of Psilocybe cubensis and Panaeolus cyanescens Magic Mushroom Extracts on Endothelin-1-Induced Hypertrophy and Cell Injury in Cardiomyocytes

Investigators examined the effects of mushroom extracts on endothelin-1-induced hypertrophy and tumor necrosis factor-α-induced cell injury in H9C2 cardiomyocytes.
[Scientific Reports]
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Eosinophils Improve Cardiac Function after Myocardial Infarction

Mechanistic studies revealed roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2– and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer.
[Nature Communications]
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Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
[Journal of Pain Research]
Hsu, J.-M., Shiue, S.-J., Yang, K. D., Shiue, H.-S., Hung, Y.-W., Pannuru, P., Poongodi, R., Lin, H.-Y., & Cheng, J.-K. (2020, December 4). <p>Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats</p>. Journal of Pain Research. https://doi.org/10.2147/JPR.S286771 Cite
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