The Effects of Citrus Flavonoids and Their Metabolites on Immune-Mediated Intestinal Barrier Disruption Using an In Vitro Co-Culture Model

Researchers assessed the effect of citrus flavonoids and their intestinal metabolites on immune-mediated barrier disruption in an in vitro co-culture model.
[British Journal of Nutrition]
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Intrinsic Cardiac Adrenergic Cells Contribute to LPS-Induced Myocardial Dysfunction

Researchers showed that norepinephrine secretion from intrinsic cardiac adrenergic cells was increased through activation of Toll-like receptor 4 to aggravate myocardial TNF-α production and dysfunction by lipopolysaccharide (LPS).
[Communications Biology]
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Chemokine CCL18 Promotes Phagocytosis Through Its Receptor CCR8 Rather than PITPNM3 in Human Microglial Cells

Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line
[Journal of Interferon and Cytokine Research]
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Inhalation of Dimethyl Fumarate-Encapsulated Solid Lipid Nanoparticles Attenuate Clinical Signs of Experimental Autoimmune Encephalomyelitis and Pulmonary Inflammatory Dysfunction in Mice

Scientists investigated the potential effects of solid lipid nanoparticles containing dimethyl fumarate, administered by inhalation on the clinical signs, central nervous system inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis.
[Clinical Science]
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A20 (TNFAIP3) Alleviates Viral Myocarditis through ADAR1/miR-1a-3p-Dependent Regulation

A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of VMC mice as well as in Coxsackie virus B3-infected cardiomyocytes.
[BMC Cardiovascular Disorders]
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LncRNA MEG3 Ameliorates NiO Nanoparticles-Induced Pulmonary Inflammatory Damage via Suppressing the p38 Mitogen Activated Protein Kinases Pathway

Wistar rats were treated with nickel oxide nanoparticles (NiO NPs) suspensions by intratracheal instillation twice-weekly for nine weeks. A549 cells were treated with NiO NPs suspensions for 24 hour.
[Environmental Toxicology]
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Hyperinflammatory Environment Drives Dysfunctional Myeloid Cell Effector Response to Bacterial Challenge in COVID-19

Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.
[PLoS Pathogens]
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Exosomes from Adipose-Derived Mesenchymal Stem Cells Alleviate Sepsis-Induced Lung Injury in Mice by Inhibiting the Secretion of IL-27 in Macrophages

The authors investigated the mechanism of exosomes from adipose-derived MSCs in sepsis-induced acute lung injury.
[Cell Death Discovery]
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TBK1 Recruitment to STING Mediates Autoinflammatory Arthritis Caused by Defective DNA Clearance

The authors found that the STING S365A mutation, which abrogated IRF3 binding and type I interferon induction, rescued the embryonic lethality of DNase II−/− mice.
[Journal of Experimental Medicine]
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CD4+ T-cell Activation of Bone Marrow Causes Bone Fragility and Insulin Resistance in Type 2 Diabetes

In type 2 diabetes mellitus mice scientists inhibited systemic activation of T cells with a fusion protein between the extracellular domain of Cytotoxic T-Lymphocyte Antigen 4 and the Fc domain of human immunoglobulin G.
[Bone]
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Polygonatum sibiricum Polysaccharides (PSP) Improve the Palmitic Acid (PA)-Induced Inhibition of Survival, Inflammation, and Glucose Uptake in Skeletal Muscle Cells

The underlying molecular mechanisms of PSP in improving insulin resistance (IR) in skeletal muscle remain unclear. PA induced an IR model in L6 myotubes. After treatment, cell proliferation was measured using the CCK8.
[Bioengineered]
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