Bioengineered In Vitro 3D Model of Myotonic Dystrophy Type 1 Human Skeletal Muscle

Biofabrication tools can be applied to engineer human three-dimensional culture systems that complement current preclinical research models. Investigators described the development of the first in vitro three-dimensional model of myotonic dystrophy type 1 human skeletal muscle.
[Biofabrication]
Fernández-Garibay, X., Ortega, M. A., Cerro-Herreros, E., Comelles, J., Martínez, E., Artero, R., Fernandez-Costa, J. M., & Ramon, J. (2021). Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle. Biofabrication. https://doi.org/10.1088/1758-5090/abf6ae Cite
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Eotaxin-1/CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis

The authors investigated the expression and function of Eotaxin-1 (CCL11) in rheumatoid arthritis fibroblast-like synoviocytes.
[Scientific Reports]
Wakabayashi, K., Isozaki, T., Tsubokura, Y., Fukuse, S., & Kasama, T. (2021). Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. Scientific Reports, 11(1), 7937. https://doi.org/10.1038/s41598-021-87199-7 Cite
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Eradication of Specific Donor-Dependent Variations of Mesenchymal Stem Cells in Immunomodulation to Enhance Therapeutic Values

Researchers analyzed human umbilical-cord-derived MSCs from 32 donors and revealed donor-dependent variations in two non-correlated properties; cell proliferation, and immune modulatory functions in vitro and in vivo, which might explain inconsistent clinical efficacies of MSCs.
[Cell Death & Disease]
Zhang, C., Zhou, L., Wang, Z., Gao, W., Chen, W., Zhang, H., Jing, B., Zhu, X., Chen, L., Zheng, C., Shi, K., Wu, L., Cheng, L., Zhang, K., & Sun, Y. E. (2021). Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values. Cell Death & Disease, 12(4), 1–11. https://doi.org/10.1038/s41419-021-03644-5 Cite
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Autophagy-Mediated Activation of Mucosal-Associated Invariant T Cells Driven by Mesenchymal Stem Cell-Derived IL-15

Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.
[Stem Cell Reports]
Song, C., Xu, W., Wu, H., Wang, X., Gong, Q., Liu, C., Liu, J., & Zhou, L. (2020). Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03136-y Cite
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The Adipose-Derived Mesenchymal Stem Cell Secretome Promotes Hepatic Regeneration in Miniature Pigs after Liver Ischemia-Reperfusion Combined with Partial Resection

24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.
[Stem Cell Research & Therapy]
Jiao, Z., Ma, Y., Zhang, Q., Wang, Y., Liu, T., Liu, X., Piao, C., Liu, B., & Wang, H. (2021). The adipose-derived mesenchymal stem cell secretome promotes hepatic regeneration in miniature pigs after liver ischaemia-reperfusion combined with partial resection. Stem Cell Research & Therapy, 12(1), 218. https://doi.org/10.1186/s13287-021-02284-y Cite
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MicroRNA-125a Correlates with Decreased Psoriasis Severity and Inflammation and Represses Keratinocyte Proliferation

Researchers investigated the correlation of miR-125a with disease severity and inflammation in psoriasis patients, and the effect of miR-125a on proliferation, apoptosis as well as its target signaling pathway in keratinocytes.
[Dermatology]
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CircRNA RSF1 Regulated Ox-LDL Induced Vascular Endothelial Cells Proliferation, Apoptosis and Inflammation through Modulating miR-135b-5p/HDAC1 Axis in Atherosclerosis

ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research]
Zhang, X., Lu, J., Zhang, Q., Luo, Q., & Liu, B. (2021). CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis. Biological Research, 54(1), 11. https://doi.org/10.1186/s40659-021-00335-5 Cite
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Artemisinin Improves Neurocognitive Deficits Associated with Sepsis by Activating the AMPK Axis in Microglia

In BV2 microglial cells treated with LPS, pre-application of artemisinin significantly reduced the production of proinflammatory cytokines and suppressed microglial migration.
[Acta Pharmacologica Sinica]
Lin, S., Wei, J., Hu, J., Bu, J., Zhu, L., Li, Q., Liao, H., Lin, P., Ye, S., Chen, S., & Chen, X. (2021). Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-021-00634-3 Cite
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TNF-α and α-Synuclein Fibrils Differently Regulate Human Astrocyte Immune Reactivity and Impair Mitochondrial Respiration

Researchers examined the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein species in astrocytes derived from induced pluripotent stem cells.
[Cell Reports]
Russ, K., Teku, G., Bousset, L., Redeker, V., Piel, S., Savchenko, E., Pomeshchik, Y., Savistchenko, J., Stummann, T. C., Azevedo, C., Collin, A., Goldwurm, S., Fog, K., Elmer, E., Vihinen, M., Melki, R., & Roybon, L. (2021). TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108895 Cite
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Anti-Mucin 1 Chimeric Antigen Receptor T Cells for Adoptive T Cell Therapy of Cholangiocarcinoma

Scientists created the fourth-generation CAR construct containing anti-MUC1-single-chain variable fragment and three co-stimulatory domains linked to CD3ζ and evaluated anti-MUC1-CAR4 T cells in cholangiocarcinoma models.
[Scientific Reports]
Supimon, K., Sangsuwannukul, T., Sujjitjoon, J., Phanthaphol, N., Chieochansin, T., Poungvarin, N., Wongkham, S., Junking, M., & Yenchitsomanus, P. (2021). Anti-mucin 1 chimeric antigen receptor T cells for adoptive T cell therapy of cholangiocarcinoma. Scientific Reports, 11(1), 6276. https://doi.org/10.1038/s41598-021-85747-9 Cite
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GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer

A dense infiltration of Tregs in mouse and human CRC lesions correlated with increased expression of the orphan chemoattractant receptor GPR15 on these cells.
[Cancer Research]
Adamczyk, A., Pastille, E., Kehrmann, J., Vu, V. P., Geffers, R., Wasmer, M.-H., Kasper, S., Schuler, M., Lange, C. M., Muggli, B., Rau, T. T., Klein, D., Hansen, W., Krebs, P., Buer, J., & Westendorf, A. M. (2021). GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2133 Cite
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