The three dihydroxystilbenes in this study inhibited colon carcinogenesis and tumor growth as well as increases in colon IL-1β, IL-6, MCP-1, and PD-1 levels in AOM/DDS-treated mice in vivo. The three dihydroxystilbenes also suppressed COX-2 expression in colon tumors in vivo and inhibited PD-1 elevations in M2-THP-1 macrophages in vitro.
[European Journal of Pharmacology]
6606345 STLMX86M items 1 apa default asc 1
Kimura, Y., Sumiyoshi, M., Kiyoi, T., & Baba, K. (2020). Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. European Journal of Pharmacology, 173445. https://doi.org/10.1016/j.ejphar.2020.173445 Cite
Researchers found increases in TNF-α and miR-31/155 levels and reduced numbers of circulating endothelial progenitor cells in patients with preeclampsia.
[Experimental and Molecular Medicine]
6445212 Z3MS2YTA items 1 apa default asc 1
Kim, J.-H., Kim, J.-Y., Park, M., Kim, S., Kim, T., Kim, J., Choi, S., Park, W., Hwang, J. Y., Choe, J., Ha, K.-S., Won, M.-H., Ryoo, S., Kwon, Y.-G., & Kim, Y.-M. (2020). NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-0478-x Cite
Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
6445212 5BSWI6DZ items 1 apa default asc 1
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
Researchers focused on the paracrine effects of rat dental follicle stem cells (DFSCs) on the inflammation and regeneration of rat injured dental pulp to detect whether DFSCs are a potential candidate for mesenchymal stem cell-based minimally invasive vital pulp therapy.
[Stem Cell Research & Therapy]
1254621 UMKAQFIT items 1 apa default asc 1
Human alveolar epithelial A549 cells were cultured for 24 hours in conditioned media of THP-1 monocyte-derived macrophages with 1–20 μM aesculetin.
[International Journal of Molecular Sciences]
1254621 SMTGZLHX items 1 apa default asc 1
Oh, S. Y., Kim, Y.-H., Kang, M.-K., Lee, E.-J., Kim, D. Y., Oh, H., Kim, S.-I., Na, W., & Kang, Y.-H. (2020). Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling. International Journal of Molecular Sciences, 21(15), 5518. https://doi.org/10.3390/ijms21155518 Cite
Scientists compiled an unbiased atlas of human colonic CD8+ T cells in health and ulcerative colitis using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry.
6445212 D4QV8RCD items 1 apa default asc 1
Corridoni, D., Antanaviciute, A., Gupta, T., Fawkner-Corbett, D., Aulicino, A., Jagielowicz, M., Parikh, K., Repapi, E., Taylor, S., Ishikawa, D., Hatano, R., Yamada, T., Xin, W., Slawinski, H., Bowden, R., Napolitani, G., Brain, O., Morimoto, C., Koohy, H., & Simmons, A. (2020). Single-cell atlas of colonic CD8 + T cells in ulcerative colitis. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-1003-4 Cite
A 96-well microplate system was developed where primary human small airway epithelial cells were cultured at an air–liquid interface (ALI). After four weeks of ALI culture, a pseudostratified epithelium containing basal, club, goblet and ciliated cells was produced.
1254621 IKDEGQ7L items 1 apa default asc 1
Bluhmki, T., Bitzer, S., Gindele, J. A., Schruf, E., Kiechle, T., Webster, M., Schymeinsky, J., Ries, R., Gantner, F., Bischoff, D., Garnett, J., & Heilker, R. (2020). Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model. Scientific Reports, 10(1), 13022. https://doi.org/10.1038/s41598-020-69948-2 Cite
Adipose tissue mesenchymal stem cells were able to delay the onset of collagen-induced arthritis, suppress the ongoing clinical and histopathological signs, decrease serum levels of TNF-α and anti-collagen type II, and downregulate the autoreactive T cells as etanercept.
1254621 X58ZAHWM items 1 apa default asc 1
El-Gendy, H., Hawass, S. E.-D., Awad, M., Mohsen, M. A., Amin, M., Abdalla, H. A., Fouad, S., & Lotfy, A. (2020). Comparative study between human mesenchymal stem cells and etanercept as immunomodulatory agents in rat model of rheumatoid arthritis. Immunologic Research. https://doi.org/10.1007/s12026-020-09132-w Cite
Researchers showed for the first time that LCN2 mRNA and protein expression were strongly inducible by TNF-α in the highly metastatic human PCa cell line PC-3.
Scientists investigated immunomodulatory potential of human Wharton’s jelly mesenchymal stem cells derived extracellular vesicles on inflammasome activity one week after spinal cord injury in rats.
1254621 CH8SZ5IJ items 1 apa default asc 1
Noori, L., Arabzadeh, S., Mohamadi, Y., Mojaverrostami, S., Mokhtari, T., Akbari, M., & Hassanzadeh, G. (2020). Intrathecal administration of the extracellular vesicles derived from human Wharton’s jelly stem cells inhibit inflammation and attenuate the activity of inflammasome complexes after spinal cord injury in rats. Neuroscience Research. https://doi.org/10.1016/j.neures.2020.07.011 Cite
Continue reading “Intrathecal Administration of the Extracellular Vesicles Derived from Human Wharton’s Jelly Stem Cells Inhibit Inflammation and Attenuate the Activity of Inflammasome Complexes after Spinal Cord Injury in Rats”
QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation.
6445212 UAMKMD78 items 1 apa default asc 1
Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J., & Margariti, A. (2020). Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nature Communications, 11(1), 3812. https://doi.org/10.1038/s41467-020-17468-y Cite
Scientists showed that exosomes produced by naive bone marrow-derived macrophages (BMDM) contained anti-inflammatory microRNA-99a/146b/378a that were further increased in exosomes produced by BMDM polarized with IL-4.
1254621 3M9S3FH7 items 1 apa default asc 1