TNF-α

[Journal of Applied Microbiology] To evaluate anti-inflammatory activities of L. reuteri LM1071, LPS-stimulated RAW264.7 cells were used. Gene expression levels of eight immune-associated genes including IL-1β, IL-6, and TNF-α and protein production levels of COX-1 and COX-2 were analyzed.

[Cell Death & Disease] Centrosomal P4.1-associated protein (CPAP) could increase the expression of chemokine ligand 16 (CCL-16), an important chemotactic cytokine in human hepatocytes. CCL-16 expression was positively correlated with CPAP and TNF-α mRNA expression in the peritumoral part of hepatocellular carcinoma.

[Brazilian Journal of Medical and Biological Research] Lower Foxp3 and higher Bcl-6, ICOS, and PD-1 mRNA expression levels were found in patients with dilated cardiomyopathy (DCM). Plasma interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-21 levels were significantly increased in DCM cases.

[Scientific Reports] Lesogaberan’s potential efficacy in non-alcoholic steatohepatitis (NASH) was tested in human stellate cells, human precision cut liver slices, and in vivo in a well-validated murine model of NASH.

[Translational Psychiatry] Scientists found that bilobalide inhibited Aβ-induced and STAT3-dependent expression of TNF-α, IL-1β, and IL-6 in primary astrocyte culture.

[Scientific Reports] Intraperitoneal injection of lipopolysaccharide and oral gavage of ampicillin increased IFN-γ and TNF-α expression in the spleen, colon, and hippocampus, while IL-10 expression decreased.