Tag results:

TNF-α

TNF-α Stimulation Enhances the Neuroprotective Effects of Gingival MSCs Derived Exosomes in Retinal Ischemia-Reperfusion Injury via the MEG3/miR-21a-5p Axis

[Biomaterials] Exosomes from the conditioned medium (CM) of gingival MSC were isolated by ultracentrifugation and were injected into the vitreous of mice. The results showed that intraocular injection of TNF-α-stimulated gingival MSC into mice with ischemia-reperfusion injury notably reduced inflammation and cell loss than that with G-exos.

IL-37 Isoform D Acts as an Inhibitor of Soluble ST2 to Boost Type 2 Immune Homeostasis in White Adipose Tissue

[Cell Death Discovery] IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, reducing obesity and insulin resistance in high-fat diet-fed mice.

In Vitro Ballooned Hepatocytes Can Be Produced by Primary Human Hepatocytes and Hepatic Stellate Cell Sheets

[Scientific Reports] Researchers engineered cell sheets to develop a new in vitro model of ballooned hepatocytes.

Alpha-7 Nicotinic Acetylcholine Receptor Agonist Alleviates Psoriasis-Like Inflammation through Inhibition of the STAT3 and NF-κB Signaling Pathway

[Cell Death Discovery] Researchers analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.

CD4+ T Cell Dysfunction in Severe COVID-19 Disease is TNFα/TNFRI-Dependent

[American Journal of Respiratory and Critical Care Medicine] Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.

Strategy of Stem Cell Transplantation for Bone Regeneration with Functionalized Biomaterials and Vascularized Tissues in Immunocompetent Mice

[ACS Biomaterials Science & Engineering] Scientists covalently modified alginate with RGD and QK peptides that were injected subcutaneously into immunocompetent mice.

Popular