PBX3-Activated DLG1-AS1 Can Promote the Proliferation, Invasion and Migration of TNBC Cells by Sponging miR-16-5p

Scientists found that PBX3-activated DLG1-AS1 could promote the proliferation, invasion and migration of TNBC cells by sponging miR-16-5p and elevating JARID2 expression.
[Molecular Therapy Oncolytics]
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O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

The stemness of OAcGD2+ cells isolated by sorting and the effects of mAb8B6 were assessed by cancer stem cell growth and mammosphere formation in vitro and tumor growth in vivo using patient-derived xenograft models.
[Frontiers in Immunology]
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Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate

Researchers reported a novel strategy to generate highly pure mouse bone marrow MSCs using liposomal clodronate.
[Tissue Engineering and Regenerative Medicine]
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Novel Function of THEMIS2 in the Enhancement of Cancer Stemness and Chemoresistance by Releasing PTP1B from MET

Scientists discovered an intrinsic signaling scaffold function of THEMIS2, which acted as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation.
[Oncogene]
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Copper Depletion Modulates Mitochondrial Oxidative Phosphorylation to Impair Triple Negative Breast Cancer Metastasis

Using two independent TNBC models, the authors reported a discrete subpopulation of highly metastatic SOX2/OCT4+ cells within primary tumors that exhibitrf elevated intracellular copper levels and a marked sensitivity to tetrathiomolybdate.
[Nature Communications]
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Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Cell lines grown in vivo more faithfully recapitulated the metabolic profiles of patient tumors compared to those grown in vitro. Integrated metabolic and gene expression analyses identified genes that strongly correlated with metabolic dysregulation and predicted patient prognosis.
[Cancer Research]
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MALT1 Is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer

Scientists demonstrated that overexpression of G protein–coupled receptors implicated in breast cancer pathogenesis, specifically the receptors for Angiotensin II and thrombin, drove a strong epithelial-to-mesenchymal transition program in breast cancer cells that was characteristic of claudin-low, TNBC.
[Molecular Cancer Research]
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The BH3-Only Protein Noxa Serves as an Independent Predictor of Breast Cancer Patient Survival and Defines Susceptibility to Microtubule Targeting Agents

The authors identified high NOXA/PMAIP mRNA expression levels as an independent prognostic marker for improved relapse-free survival and overall survival in multivariate analysis in breast cancer patients, independent of their molecular subtype.
[Cell Death & Disease]
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Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy

The authors described the synthesis of multiple bromodomain-containing protein 4 (BRD4)– casein kinase 2dual inhibitors based on rational drug design, structure–activity relationship, and in vitro and in vivo evaluations, and 44e was identified to possess potent and balanced activities against BRD4.
[Journal of the American Chemical Society]
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Excellent Effects and Possible Mechanisms of Action of a New Antibody–Drug Conjugate against EGFR-Positive Triple-Negative Breast Cancer

Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.
[Military Medical Research]
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FDI-6 Inhibits the Expression and Function of FOXM1 to Sensitize BRCA-Proficient Triple-Negative Breast Cancer Cells to Olaparib by Regulating Cell Cycle Progression and DNA Damage Repair

Scientists found that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor FDI-6 could sensitize BRCA-proficient TNBC to PARP inhibitor Olaparib in vitro and in vivo.
[Cell Death & Disease]
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