triple negative breast cancer

[npj Precision Oncology] The authors presented a next-generation sequencing methylation-based blood test called methylation DETEction of Circulating Tumour DNA (mDETECT) designed for the optimal detection and monitoring of metastatic TNBC.

[Cancer Cell International] Reverse transcription-quantitative polymerase chain reaction was performed to confirm the downregulation of circ_0044234 in triple negative tumors and cell lines versus non-triple negative ones.

[Cancer Cell International] Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.

[Oncoimmunology] Scientists exploited cytokine-induced killer cells' expression of FcγRIIIa in combination with clinical-grade monoclonal antibodies to redirect their lytic activity in an antigen-specific manner, and reported the efficacy of this combined approach against TNBC.

[Science Signaling] The authors investigated the metabolic vulnerabilities of TNBC, particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics.

[Journal of Cellular Physiology] The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.