triple negative breast cancer

[Scientific Reports] Investigators found that the zinc complex of 3,5-di-tert-butyl salicylate compound inhibited viability, invasion, and migration and induced apoptosis in triple-negative breast cancer 4T1 cells.

[Nature Cancer] Researchers showed that immune-checkpoint blockade (ICB) therapy selects for ligand-dependent corepressor (LCOR)low CSCs with reduced antigen processing/presentation machinery driving immune escape and ICB resistance in triple-negative breast cancer.

[Cell Reports] Scientists reported that tumor-derived Jagged1 is a key regulator of the tumor immune microenvironment. Jagged1 promoted tumorigenesis in multiple spontaneous mammary tumor models.

[Cancer Research] The authors showed that decellularized ECM (dECM) obtained from chemotherapy-treated mice increased motility of treatment-naïve breast cancer cells compared to vehicle-treated dECM.

[npj Breast Cancer] In order to gain insight into pathways that contributed to the divergent sensitivity to chemotherapy, scientists compared the inflammatory profile of the TNBC subtypes treated with docetaxel.

[Scientific Reports] The authors investigated the expression profile of 48 apoptotic and 35 oxidative gene markers after canady helios cold plasma treatment in six different types of breast cancer cell lines.