triple negative breast cancer

[Breast Cancer Research and Treatment] MDA-MB-231-HM cells secreted exosomes enriched matrix metalloproteinase-1 (MMP-1), which could be taken up and enhanced invasion and migration activities of TNBC cells, including MDA-MB-231, MDA-MB-468 and BT549.

[Oncogene] Researchers identified a 21-amino-acid survival-associated micropeptide XBP1SBM, encoded by the long non-coding RNA (lncRNA) MLLT4-AS1, which was upregulated in TNBC tissues and glutamine-deprived TNBC cell lines.

[Cell Reports] Investigators reported a comprehensive proteomic study of a 90-case cohort of paired samples of TNBC in quantification, phosphorylation, and DNA-binding capacity.

[Cell Death Discovery] Researchers demonstrated that circular RNA PRKCI (circPRKCI), derived from the PRKCI gene, was elevated in breast cancer tissues and cell lines, especially in TNBC.

[Acta Pharmacologica Sinica] Researchers suggested that Scutellarin reduced triple-negative breast cance metastasis by suppressing tumor necrosis factor-α (TNFα)-initiated vascular endothelial barrier breakdown through rescuing the reduced expression of junctional proteins by regulating the TNF receptor 2-extracellular signal-regulated protein kinase1/2-enhancer of zeste homolog-2 signaling pathway.

[Nature Cancer] Researchers reported a bank of human patient-derived xenografts and matched organoid cultures from tumors that represented the greatest unmet need: endocrine-resistant, treatment-refractory, and metastatic breast cancers.