triple negative breast cancer

[Advanced Science] RNA-seq analysis and coimmunoprecipitation assays indicated that HTR1A interacted with TRIM21 and PSMD7 to inhibit the degradation of TβRII through the ubiquitin-proteasome pathway.

[Molecular Therapy-Nucleic Acids] The authors demonstrated that triple negative breast cancer cell-derived exosomes increased normal fibroblast collagen contraction and migration alongside cancer-associated fibroblasts molecular markers.

[Nature Communications] Researchers demonstrated that Lin28B promoted lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.

[Journal of Cellular and Molecular Medicine] Scientists review the recent progress of TNBC research in transcriptomics and proteomics to identify possible therapeutic goals and improve the survival of patients with TNBC.

[Nature Communications] Integrated copy number and transcriptome analysis of 302 TNBC patients revealed that gene alpha-endosulfine (ENSA) exhibited recurrent amplification at the 1q21.3 region and was highly expressed in TNBC.

[Cell Death & Disease] Knockout of diacylglycerol kinase ζ (DGKZ) in TNBC cell lines were found to significantly inhibit metastatic behaviors in vitro and in vivo, whereas its overexpression increased the metastatic potential of cell lines.