tuberculosis

[Thorax] Scientists discuss the interplay between lung endothelial cell, immune cells and Mycobacterium tuberculosis (Mtb) and argue that modeling these interactions is of key importance to unravel early events during Mtb infection.

[mBio] Scientists performed an in-depth study of myeloid-derived suppressor cells during latent tuberculosis (TB) infection and active TB using the nonhuman primate (NHP) model of pulmonary TB.

[Scientific Reports] miR-375-3p, the pulmonary TB specific marker was found in higher amount in the plasma of intestinal tuberculosis patients than Crohn’s disease while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients.

[NPJ Vaccines] Scientists exploited the immunostimulatory properties of bacille Calmette-Guérin, the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity.

[Cell Reports] To better understand Bacillus Calmette-Guérin (BCG)-induced immune reprogramming, investigators performed single-cell transcriptomic measurements before and after BCG vaccination using secondary immune stimulation with bacterial lipopolysaccharide.

[Frontiers in Imm] The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.