tuberculosis

[Cell Reports] Scientists characterized the metabolic and transcriptional responses of murine macrophages to Mycobacterium tuberculosis in order to disentangle the underlying mechanisms.

[Peptides] Scientists investigated the role of ascorbic acid, calcitriol, retinoic acid, and alfa-tocopherol as inductors of molecules related to mycobacterial contention in macrophages and epithelial cells.

[Nature Immunology] The authors integrated single-cell RNA and surface protein data from 500,089 memory T cells to define 31 cell states from 259 individuals in a Peruvian tuberculosis progression cohort.

[Frontiers in Immunology] Utilizing an in vitro system, scientists identified that macrophages relied on nitric oxide (NO) for only half of their L-arginine-mediated host defenses and this L-arginine-mediated defense in the absence of NO was associated with enhanced macrophage numbers and viability.

[Journal of Clinical Investigation] Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.

[Scientific Reports] Researchers characterized the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4+ and CD8+ T cells, NK cells, B cells, monocyte subsets and myeloid dendritic cells.